吉西他滨与长春瑞滨治疗晚期非小细胞肺癌的比较研究

目的 比较吉西他滨联合顺铂组成的GP方案与长春瑞滨(去甲长春花碱)联合顺铂组成的NP方案，治疗晚期非小细胞肺癌(NSCLC)的近期疗效和毒性。方法 通过GP和NP两个联合化学治疗方案治疗晚期非小细胞肺癌68例。结果 GP组和NP组有效率分别为47．2％和43．8％，两组无显著性差异(P＞0．05)。不良反应主要是骨髓押制。结论 吉西他滨联合顺铂方案与去甲长春花碱联合顺铂方案治疗晚期非小细胞肺癌疗效较高且相似。不良反应可以耐受。

Comparative study of vinorelbine and gemcitabine in the treatment of advanced non-small cell lung cancer

OBJECTIVE To evaluate and compare the effects and toxicity of GP(GEM+DDP) and norvinblastine (NVB+DDP) treatment regimen for terminal non small cell lung cancer(NSCLC). METHOD 68 cases of NSCLC were divided into GP and NP group.RESULTS The response rate were 47.2%(17/36) for GP regimen and 43.8%(14/32) for NP regimen respectively. There was no statistical significant difference ( P > 0.05) between them. The major toxicity was bone marrow suppression.CONCLUSION The combination of gemcitabine and cisplatin in the treatment of non small cell lung cancer has the same high response rate as that of norvinblastine combined with cisplatin.