| 正交试验优化复方三草滴丸制备工艺 |
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| 引用本文： | 何丽君,徐小妹,鄢英慧,陈豪,秦笑笑,程心玲,徐榕青.正交试验优化复方三草滴丸制备工艺[J].中国现代应用药学,2018,35(9):1355-1359. |
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| 作者姓名： | 何丽君 徐小妹 鄢英慧 陈豪 秦笑笑 程心玲 徐榕青 |
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| 作者单位： | 福建中医药大学附属人民医院药学部, 福州 350004,福建省医学科学研究院福建省医学测试重点实验室, 福州 350001,福建中医药大学附属人民医院药学部, 福州 350004,福建中医药大学附属人民医院药学部, 福州 350004,福建中医药大学附属人民医院药学部, 福州 350004,福建中医药大学附属人民医院药学部, 福州 350004,福建省医学科学研究院福建省医学测试重点实验室, 福州 350001 |
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| 基金项目： | 福建省科技计划项目（2014Y0060） |
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| 摘 要： | 目的 优选复方三草滴丸制备工艺的最佳条件，并测定滴丸中熊果酸的含量。方法 以滴丸的硬度、圆整度、拖尾度、黏连为评价指标，采用正交试验设计方法优选滴丸制备工艺；采用HPLC测定滴丸中熊果酸的含量。结果 滴丸的最佳制备工艺：药物与基质配比为1∶2，PEG 4000与PEG 6000的配比为2∶1，适宜料温为80℃，滴速为每分钟40滴；HPLC测得滴丸中熊果酸的含量为0.992 5 mg·g-1。结论 复方三草滴丸制备工艺简便、可行，得到的滴丸圆整度较高、色泽较亮、成形良好、质量可控。熊果酸含量测定方法稳定、可靠，可用于滴丸的质量控制。
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| 关 键 词： | 复方三草滴丸 正交试验 熊果酸 高效液相色谱法 |
| 收稿时间： | 2017/11/29 0:00:00 |
| 修稿时间： | 2018/2/9 0:00:00 |
Optimization of Preparation Process of Compound Three Herbs Droplet by Orthogonal Experiment |
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| HE Lijun,XU Xiaomei,YAN Yinghui,CHEN Hao,QIN Xiaoxiao,CHENG Xinling and XU Rongqing.Optimization of Preparation Process of Compound Three Herbs Droplet by Orthogonal Experiment[J].The Chinese Journal of Modern Applied Pharmacy,2018,35(9):1355-1359. |
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| Authors: | HE Lijun XU Xiaomei YAN Yinghui CHEN Hao QIN Xiaoxiao CHENG Xinling and XU Rongqing |
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| Affiliation: | Department of Pharmacy, People''s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,Fujian Provincial Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China,Department of Pharmacy, People''s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,Department of Pharmacy, People''s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,Department of Pharmacy, People''s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,Department of Pharmacy, People''s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China and Fujian Provincial Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China |
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| Abstract: | |
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| Keywords: | Compound Three Herbs droplet orthogonal experiment ursolic acid HPLC |
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