1-[2-(N-甲基)氨基-2-(2,4-二氯苯基)乙基]-1H-1,2,4-三唑化合物的合成

目的：改进1－2-（N－甲基）氨基－2－（2，4－二氯苯基）乙基]-1H-1,2,4-三唑的合成方法，降低成本，提高收率，方法：以2－氯－1－（2，4－二氯苯基）乙酮为原料，经三唑烷基化与甲胺反应生成酮亚胺后还原（A法），或与N－甲基甲酰胺进行Leukart反应（B法），结果：A和B两种方法制得目标化合物的收率分别为57．6％和63．2％。结论：A和B两种方法原料易得，反应简便，降低了成本，提高了收率。

SYNTHESIS OF 1-[2-(N-METHYL)AMINO-2-(2,4-DICHLORO PHENYL)ETHYL]-1H-1,2,4-TRIAZOLE

OBJECTIVE:To improve the synthetic method of 1 2 (N methyl)amino 2 (2,4 dichloro) phenyl] 1H 1,2,4 triazole,lower its cost and raise its yeild.METHOD: The title compound was prepared from 2 chloro 1 (2,4 dichlorophenyl)ethyl ketone by triazolyl alkylation,reaction with methylamine and ketimine reduction(method A) or Leukart reaction with N methyl foramide(method B).RESULT: The yields of method A and B to get 1 2 (N methyl)amino 2 (2,4 dichloro) phenyl] 1H 1,2,4 triazole was 63.2% and 57.6% respectively.CONCLUSION: The advantages of this synthesis route were that the material was easy to obtain,the production cost was reduced and the yield was raised.