芦荟胶外涂对大鼠背部创面愈合和疤痕形成的影响

目的：研究芦荟胶外涂对大鼠背部创面愈合及疤痕形成的影响。方法：36只健康雄性大鼠随机分为空白组、实验组和对照组,建立大鼠背部切创伤模型,外涂创面给药后,以创伤面积愈合率和皮肤组织中毛囊、皮脂腺、胶原纤维等的生成情况来评价愈合效果。结果：与空白组相比,实验组上皮出现时间早,创面愈合时间较短,伤口愈合率明显提高(P<0.05),皮肤组织中毛囊、皮脂腺等附属器官及Ⅲ型胶原纤维的生成较多,胶原蛋白束排列较为有序；实验组各项指标与对照组接近。结论：芦荟胶对于皮肤创伤有着较好的治疗效果,并且可以抑制疤痕的形成。

Effect of Aloe Vera Gel on Wound Healing and Scar Formation in Back of Rats

Objective: Explore the effect of aloe gel on wound healing and scar formation in back of rats. Methods: 36 healthy and male rats were randomly divided into blank control group, experimental group and control group, the model of dorsal wound in rats was established, after applied topically administered, the wound healing rate and the formation of hair follicles, sebaceous glands and collagen fibers in the skin tissues were evaluated. Results: Compared with the blank group, the appearing time of epithelium in the aloe gel group was earlier, the healing time was shorter, and the healing ratio was obviously improved (P<0.05), the contents of hair follicles, sebaceous glands and other accessory organs and type III collagen fibers were more abundant in the skin tissues, collagen bundles were arranged more orderly; The indexes of the experimental group were close to that of the control group. Conclusion: Aloe gel has a better therapeutic effect for skin trauma, and can inhibit the formation of scar.