美托洛尔对冠心病心绞痛患者心肌缺血总负荷及心率变异性的影响

目的探析冠心病心绞痛患者应用美托洛尔治疗后心率变异性和心肌缺血总负荷的变化。方法90例冠心病心绞痛患者,根据治疗方法不同分为对照组和观察组,每组45例。对照组患者采用常规治疗,观察组患者在常规治疗基础上采用美托洛尔治疗。对比两组患者治疗前后心肌缺血总负荷情况及心率变异性、心绞痛发作情况。结果治疗后,两组患者心肌缺血总负荷均低于本组治疗前,且观察组心肌缺血总负荷(190.2±20.1)明显低于对照组的(285.5±20.4),差异具有统计学意义(P<0.05)。治疗后,观察组患者RR间期平均值标准差(SDANN)、相邻窦性RR间期差值>50 ms的心搏数占窦性RR间期总搏数的百分比(PNN50)、相邻正常RR间期差值的均方(RMSSD)、24 h窦性心搏RR间期的标准差(SDNN)分别为(108.4±12.1)ms、(15.1±3.4)%、(43.6±9.0)ms、(112.4±18.1)ms,均高于对照组的(98.5±11.4)ms、(12.1±3.9)%、(38.4±8.1)ms、(102.1±15.1)ms,差异具有统计学意义(P<0.05)。观察组患者心绞痛持续时间短于对照组,心绞痛发作次数少于对照组,差异具有统计学意义(P<0.05)。结论针对冠心病心绞痛患者,在临床治疗中应用美托洛尔治疗能够改善患者心率变异性,同时明显降低患者心肌缺血总负荷,缓解心绞痛临床症状,具有临床推广应用价值。

Effect of metoprolol on total ischemic burden and heart rate variability in patients with angina pectoris of coronary heart disease

Objective To discuss the changes of total ischemic burden and heart rate variability in patients with angina pectoris of coronary heart disease after treatment with metoprolol.Methods A total of 90 patients with angina pectoris of coronary heart disease were divided into control group and observation group according to different treatment methods,with 45 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with metoprolol based on the control group.The total ischemic burden,heart rate variability and angina pectoris attacks before and after treatment were compared between the two groups.Results After treatment,the total ischemic burden of the two groups were lower than those before treatment,and the total ischemic burden(190.2±20.1)of the observation group was obviously lower than(285.5±20.4)of the control group,and the difference was statistically significant(P<0.05).After treatment,the standard deviation average of NN intervals(SDANN),percentage of differences>50 ms between adjacent normal number of intervals(PNN50),root mean square of successive difference(RMSSD)and 24 h standard deviation of NN intervals(SDNN)of the observation group were(108.4±12.1)ms,(15.1±3.4)%,(43.6±9.0)ms and(112.4±18.1)ms,which were all higher than(98.5±11.4)ms,(12.1±3.9)%,(38.4±8.1)ms and(102.1±15.1)ms of the control group,and the difference was statistically significant(P<0.05).The duration of angina pectoris in the observation group was shorter than that in the control group,and the number of angina pectoris attacks was less than that in the control group.The difference was statistically significant(P<0.05).Conclusion For patients with angina pectoris of coronary heart disease,metoprolol can improve heart rate variability,significantly reduce the total ischemic burden,and relieve the clinical symptoms of angina pectoris.It contains clinical promotion and application value.