口服喷雾干燥乳剂处方筛选

目的优化喷雾干燥乳剂处方。方法联用羟丙甲纤维素（HPMC）和蔗糖作固体载体,椰子油作油相,采用喷雾干燥工艺制备O/W型干乳剂。结果根据乳化性能及喷雾可操作性筛选出适于采用喷雾干燥法制备干乳剂的处方。即固体载体HPMC适宜黏度为3mPa.s,浓度为8%。结论HPMC的黏度和浓度对液体O/W乳剂的稳定性及经喷雾干燥制成干乳剂有一定影响,含高黏度HPMC的液体O/W乳剂不容易雾化,易堵塞雾化器的喷嘴。低黏度HPMC是一种有用的固体载体,并起到一定的乳化作用。

Screening the formulation of oral spray-dry emulsion

Objective Screening the formulation of oral spray-dry emulsion.Methods Oral dry emulsions were prepared by spray drying liquid o/w-emulsions using hydroxypropyl methyl cellulose（HPMC）and sucrose as solid carriers and coconut oil as lipid phase.Results The formulation was optimized by the primary emulsion stability and the feasibility of spray drying.It was demonstrated that 8%HPMC（3 mPa·s）should be the optimum carrier.Conclusion It was concluded that the different types and concentrations of HPMC had effect on the forming of liquid o/w-emulsions,and too viscous liquid o/w-emulsions were difficult to atomize and were prone to jam the nozzle of the spray dryer.So low viscosity HPMC was a useful solid carrier and had the function of emulsification as emulsifiers.