Third-generation antiepileptic drugs: mechanisms of action,pharmacokinetics and interactions |
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| Authors: | Jarogniew J Łuszczki |
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| Affiliation: | 1. Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland;2. Department of Physiopathology, Institute of Agricultural Medicine, Jaczewskiego 2, PL 20-950 Lublin, Poland |
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| Abstract: | This review briefly summarizes the information on the molecular mechanisms of action, pharmacokinetic profiles and drug interactions of novel (third-generation) antiepileptic drugs, including brivaracetam, carabersat, carisbamate, DP-valproic acid, eslicarbazepine, fluorofelbamate, fosphenytoin, ganaxolone, lacosamide, losigamone, pregabalin, remacemide, retigabine, rufinamide, safinamide, seletracetam, soretolide, stiripentol, talampanel, and valrocemide. These novel antiepileptic drugs undergo intensive clinical investigations to assess their efficacy and usefulness in the treatment of patients with refractory epilepsy. |
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| Keywords: | antiepileptic drugs brivaracetam carabersat carisbamate DP-valproic acid drug interactions eslicarbazepine fluorofelbamate fosphenytoin ganaxolone lacosamide losigamone pharmacokinetics pregabalin remacemide retigabine rufinamide safinamide seletracetam soretolide stiripentol talampanel valrocemide |
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