| 5-氟尿嘧啶聚乙二醇-聚十六烷基氰丙烯酸酯纳米粒的制备 |
| |
| 引用本文： | 陈婷,贾军,王东凯,叶林茂,张晓君,崔文奇,冷迪,李翔.5-氟尿嘧啶聚乙二醇-聚十六烷基氰丙烯酸酯纳米粒的制备[J].中国新药杂志,2008,17(23). |
| |
| 作者姓名： | 陈婷 贾军 王东凯 叶林茂 张晓君 崔文奇 冷迪 李翔 |
| |
| 作者单位： | 1. 沈阳药科大学药学院,沈阳,110016
2. 沈阳活森药物研究所,沈阳,110179 |
| |
| 摘 要： | 目的:以聚乙二醇-聚十六烷基氰丙烯酸酯(PEG-PHDCA)聚合物制备5-氟尿嘧啶(5-Fu)纳米粒,并对其进行体外释药研究.方法:采用溶剂扩散法制备5-Fu PEG-PHDCA纳米粒,在单因素基础上采用正交设计法优化得到最佳处方,并对5-Fu聚合物纳米粒的粒径、Zeta电位、载药量、包封率和体外释放进行了研究.结果:制得的5-Fu聚合物纳米粒的平均粒径为132 nm,Zeta电位为-(12±2)V,载药量为12.3%,包封率为48.8%.体外释放研究发现,5-Fu PEG-PHDCA纳米粒释药近似符合Higuchi释药模型:Q=0.564 4+8.386t1/2(r=0.996 0).结论:采用溶剂扩散法制备5-Fu聚合物纳米粒方法简单,重现性好,其体外释放显示出明显缓释作用.
|
| 关 键 词： | 5-氟尿嘧啶 聚乙二醇-聚十六烷基氰丙烯酸酯 纳米粒 溶剂扩散法 体外释放 |
Preparation of 5-fluorouracil polymer nanoparticles |
| |
| CHEN Ting,JIA Jun,WANG Dong-kai,YE Lin-mao,ZHANG Xiao-jun,CUI Wen-qi,LENG Di,LI Xiang.Preparation of 5-fluorouracil polymer nanoparticles[J].Chinese Journal of New Drugs,2008,17(23). |
| |
| Authors: | CHEN Ting JIA Jun WANG Dong-kai YE Lin-mao ZHANG Xiao-jun CUI Wen-qi LENG Di LI Xiang |
| |
| Affiliation: | CHEN Ting1,JIA Jun2,WANG Dong-kai1,YE Lin-mao1,ZHANG Xiao-jun1,CUI Wen-qi1,LENG Di1,LI Xiang1(1 School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China,2 Watson Pharmaceutical Institute of Shenyang,Shenyang 110179,China) |
| |
| Abstract: | Objectives:To prepare 5-fluorouracil(5-Fu) loaded nanoparticles using the biodegradable poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate)(PEG-PHDCA),and to study the characteristics and in vitro release behaviors of the nanoparticles.Methods:5-Fu loaded nanoparticles(NPs) were made by the solvent exchange(nanoprecipitation) method with PEG-PHDCA as carrier materials.The influence of formulation and manufacture was studied with drug loading and encapsulation efficiency as evaluation ... |
| |
| Keywords: | 5-fluomuracil PEG-PHDCA nanoparticles solvent exchange method in vitro release |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
