| 新型喹诺酮类抗菌药加雷沙星 |
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| 引用本文： | 徐佳骏,崔岚.新型喹诺酮类抗菌药加雷沙星[J].中国新药杂志,2008,17(20):1808-1810. |
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| 作者姓名： | 徐佳骏 崔岚 |
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| 作者单位： | 上海交通大学医学院附属仁济医院药剂科,上海,200127 |
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| 摘 要： | 加雷沙星为一新型广谱喹诺酮类抗茵药,它不仅保持了喹诺酮类抗菌药对G-菌的抗茵活性,对G 菌的抗菌活性也明显增强,临床主要用于治疗呼吸系统感染,泌尿系统感染和皮肤,软组织感染等疾病.其结构中喹诺酮母核6位去除氟不但可以改善活性,而且可降低药物不良反应.现对其药动学、药理作用、临床应用及安全性等作一综述.
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| 关 键 词： | 喹诺酮类抗菌药 加雷沙星 抗菌谱 安全性 |
Garenoxacin,a novel quinolone antimicrobial agent |
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| XU Jia-jun,Cui Lan.Garenoxacin,a novel quinolone antimicrobial agent[J].Chinese Journal of New Drugs,2008,17(20):1808-1810. |
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| Authors: | XU Jia-jun Cui Lan |
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| Affiliation: | Department of Pharmacy;Renji Hospital;School of Medical;Shanghai Jiaotong University;Shanghai 200127;China |
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| Abstract: | Garenoxacin is a novel,broad-spectrum quiolone.It remains the antimicrobial activity against Gram-negative bacteria,and remarkably enhances the activity against Gram-positive bacteria.It is mainly used for various infections,such as the infection of respiratory system,urinary system,cutis and parenchyma systems.As compared to other quiolones,the des-F6-quinolone not only can improve anti-bacterial activity,but also reduce adverse drug reactions(ADRs).Currently,it has come into the market in Japan.In this ar... |
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| Keywords: | quinolone garenoxacin pharmacokinetics anti-bacterial spectrum safety |
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