| 与肿瘤的抗血管生成治疗相关的生物标志物 |
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| 引用本文： | 景霞,郭青龙,卢娜,徐媛媛.与肿瘤的抗血管生成治疗相关的生物标志物[J].药学服务与研究,2009,9(3):186-190. |
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| 作者姓名： | 景霞 郭青龙 卢娜 徐媛媛 |
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| 作者单位： | 1. 南京医科大学附属南京儿童医院,南京,210008
2. 中国药科大学江苏省肿瘤发生与干预重点实验室,南京,210009 |
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| 摘 要： | 抗血管生成药物的抗肿瘤机制与化疗药物不同，细胞毒药物的生物标志物对抗血管生成药物来说未必适用，因此寻找和选择有关的生物标志物对于抗血管生成治疗来说十分必要。目前一些与血管生成相关的蛋白质、内皮细胞、微血管密度等已在抗肿瘤血管生成的研究中越来越受到重视。本文将围绕以上这些与抗血管生成治疗相关的生物标志物的检测手段，以及它们在剂量指示、早期临床受益、耐药性出现和二线治疗选择等方面的应用进行综述。
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| 关 键 词： | 生物标志物 血管生成抑制剂 肿瘤 综述 |
Biomarkers relevant to tumor anti-angiogenic therapy |
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| JING Xia,GUO Qing-long,LU Na,XU Yuan-yuan.Biomarkers relevant to tumor anti-angiogenic therapy[J].Pharmaceutical Care and Research,2009,9(3):186-190. |
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| Authors: | JING Xia GUO Qing-long LU Na XU Yuan-yuan |
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| Affiliation: | 1. Nanjing Children＇s Hospital affiliated to Nanjing Medical University, Nanjing 210008, China ; 2. Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | The anti-tumor mechanisms of anti-angiogenic drugs and cytotoxic agents are different. Since biomarkers for cytotoxie agents are not optimal for anti-angiogenic drugs,it is necessary to search biomarkers for the anti-angiogenesis therapy. Angiogenesis related biomarkers, such as circulating proteins, circulating endothelial cells （CEC） and microvessel density （MVD）, have been received more and more attention. This review will focus on detection of these biomarkers, and their application in selecting dosage, evaluating early clinical benefit, predicting emergence of resistance and selecting second-line treatments, etc. |
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| Keywords: | biomarker angiogenisis inhibitors neoplasm review |
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