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| 灯盏花素磷脂复合物的表征 | |
| 引用本文： | 刘宏,唐晓荞,王影,杨祥良.灯盏花素磷脂复合物的表征[J].医药导报,2010,29(11):1395-1397. |
| 作者姓名： | 刘宏 唐晓荞 王影 杨祥良 |
| 作者单位： | 1. 广州军区武汉总医院药剂科,430070 2. 湖北省疾病预防控制中心,武汉,430079 3. 国家知识产权局,北京,100088 4. 华中科技大学生命科学与技术学院,武汉,430074 |
| 摘 要： | 目的表征灯盏花素与磷脂形成的复合物。方法通过红外光谱法、差示扫描量热法（DSC）、激光粒度分析仪表征灯盏花素磷脂复合物的红外光谱、DSC曲线和粒度。结果灯盏花素磷脂复合物的红外光谱为灯盏花素和磷脂酰胆碱二者红外光谱的叠加。DSC结果显示，复合物的相变温度降低，物理混合物的相变温度出现重叠，但相变温度的范围并无明显改变。灯盏花素磷脂复合物的水分散体在低浓度时呈胶体状，在浓度较高时则呈混悬状，稀溶液在电镜下外观为圆整的球形颗粒。激光粒度测定仪测得灯盏花素磷脂复合物水分散体的平均粒径为831.7 nm。 结论初步确定灯盏花素与磷脂间的复合为一弱的相互作用。 |
| 关 键 词： | 灯盏花素 磷脂酰胆碱 红外光谱 差示扫描量热法 |
Characterization of Scutellarin Phospholipid Complex |
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| LIU Hong,TANG Xiao-qiao,WANG Ying,YANG Xiang-liang.Characterization of Scutellarin Phospholipid Complex[J].Herald of Medicine,2010,29(11):1395-1397. | |
| Authors: | LIU Hong TANG Xiao-qiao WANG Ying YANG Xiang-liang |
| Affiliation: | LIU Hong1,TANG Xiao-qiao2,WANG Ying3,YANG Xiang-liang4(1.Department of Pharmacy,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,China,2.Hubei Protincial Center for Disease Control and Prevention,Wuhan 430079,3.State Intellectual Property Office,Beijing 100088,4.School of Life of Science and Technology,Huazhong University Science and Technology,Wuhan 430074,China) |
| Abstract: | Objective To characterise the scutellarin phospholipid complex.Methods Infrared spectroscopy (IR),differential scanning calorimetry (DSC) and laser particle size analyzer were use to detect the character of scutellarin phospholipid complex.Results DSC showed that phase transition temperature of the complex was slightly lower than those of scutellarin and phospholipid without significant change of range.When it was dispersed in water,the comlex appeared as a colloid at low temperature,while as a suspension a... |
| Keywords: | Scutellarin Phospholipid IR DSC |
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