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高寒菊科植物提取物中α-葡萄糖苷酶抑制剂的筛选
引用本文:黄元,陈睿,马继雄,陈振宁,曾阳.高寒菊科植物提取物中α-葡萄糖苷酶抑制剂的筛选[J].中国药科大学学报,2008,39(6):566-569.
作者姓名:黄元  陈睿  马继雄  陈振宁  曾阳
作者单位:青海师范大学生命与地理科学学院,西宁,810008
基金项目:青海省科技厅资助项目  
摘    要:目的:从高寒菊科植物中筛选α-葡萄糖苷酶抑制剂.方法:采用α-葡萄糖苷酶活性测定方法,对37种经水提取的高寒菊科植物进行了α-葡萄糖苷酶抑制活性的筛选.结果:在样品浓度0.625mg/mL反应体系下,5种高寒菊科植物水提取物显著抑制α-葡萄糖苷酶活性,抑制率达到50%上.结论:α-葡萄糖苷酶活性测定结果显示,某些高寒菊科植物提取物能显著抑制a-葡萄糖苷酶活性,如果对其进一步的分离、纯化并提取活性部位,有望获得高活性的α-葡萄糖苷酶抑制荆.

关 键 词:高寒菊科植物提取物  α-葡萄糖苷酶抑制剂  活性筛选

Screening of alpha-glucosidase inhibitors from the alpine Compositae herb extracts
HUANG Yuan,CHEN Rui,MA Ji-xiong,CHEN Zhen-ning,ZENG Yang.Screening of alpha-glucosidase inhibitors from the alpine Compositae herb extracts[J].Journal of China Pharmaceutical University,2008,39(6):566-569.
Authors:HUANG Yuan  CHEN Rui  MA Ji-xiong  CHEN Zhen-ning  ZENG Yang
Affiliation:HUANG Yuan,CHEN Rui,MA Ji-xiong,CHEN Zhen-ning,ZENG Yang College of Life , Geographical Sciences,Qinghai Normal University,Xining 810008,China
Abstract:Aim:To screen alpha-glucosidase inhibitors from alpine Compositae herbs(ACH).Methods:By determining alpha-glucosidase enzyme activity,37 kinds of ACH water extracts were tested in search of alpha-glucosidase inhibitors.Results:It was found that 5 kinds of ACH water extracts at the concentraction of 0.625 mg/mL inhibited alpha-glucosidase and that their inhibitory rates were above 50%.Conclusion:It was indicated that the extracts of ACH had inhibitory activities on alpha-glucosidase.Therefore,ACH is suggeste...
Keywords:alpine Compositae herbs extract  alpha-glucosidase inhibitor  activity screening  
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