山茱萸总萜对db/db糖尿病小鼠的降血糖作用

为评价山茱萸总萜对2型糖尿病的降血糖作用，对db/db糖尿病小鼠每日灌胃给予25，50，100 mg/kg山茱萸总萜共10周，每2周眼眶采血测定空腹血糖1次。于末次给药24 h后采血测定空腹血糖、胰岛素(Ins)、糖化血清蛋白(GSP)、总胆固醇(TC)、三酰甘油(TG)。给药第8和10周分别进行葡萄糖和淀粉糖耐量试验。结果显示，给药4周后，山茱萸总萜各剂量组db/db小鼠的空腹血糖有明显降低(P<；0.05)。给药10周后，山茱萸总萜25，50，100 mg/kg组db/db小鼠血清中TC、TG水平显著降低(P<；0.05)，血清糖化蛋白水平明显降低(P<；0.05)，db/db小鼠的葡萄糖耐量和灌胃淀粉糖耐量也有明显改善(P<；0.05)。研究结果提示，山茱萸总萜可调节体内糖、脂等代谢过程，对糖尿病具有一定的治疗作用。

Hypoglycemic effects of terpenes from Fructus Corni on db/db diabetic mice

To investigate the hypoglycemic effects of terpenes from Fructus Corni(TFC)on type 2 diabetes mellitus, the db/db diabetic mice were intragastrically administered with 25, 50, 100 mg/kg of TFC for 10 weeks. The fasting blood glucose, insulin(Ins), glycosylated serum protein(GSP), total cholesterol(TC)and triglyceride(TG)levels were determined. At weeks 8 and 10, intraperitoneal injections of glucose and gavage starch tolerance tests were performed, respectively. The db/db mice showed obvious obesity. Each dose of TFC could significantly reduce the body weight of db/db mice(P< 0. 05). After 4 weeks of administration, all doses of TFC significantly reduced the fasting blood glucose of db/db mice(P< 0. 05). The serum TC, TG levels were also significantly decreased in the TFC middle- and high-dose groups(P< 0. 05). In addition, middle- and high-dose of TFC could significantly reduce the level of GSP. Middle- and high-dose of TFC also significantly improve the glucose tolerance and gavage starch tolerance in db/db mice(P< 0. 05). These results suggest that TFC could improve diabetes-related symptoms via regulating glucose and lipids metabolism.