原位凝胶在牙周炎治疗中的应用及其研究进展

近年来，原位凝胶作为一种局部药物递送系统，因其良好的病灶可注入性、局部药物储库功能、药物缓释作用等特点，在牙周炎治疗中受到广泛关注，将不同类型的药物（如抗菌药物、生物活性因子等）载入原位凝胶可实现不同的治疗目的。本文总结了温度敏感型、离子敏感型、pH敏感型、溶剂交换型等各类型原位凝胶在牙周给药中的应用及局限，并对原位凝胶在消除牙周炎症、修复牙周组织以及装载微球后的长效治疗作用进行了综述。

Application and research progress of in situ gel for local treatment of periodontitis

Recently, in situ gel has been widely used as a local delivery system for periodontitis treatment because of its lesion injectability, local drug depot function, and drug sustained-release effect.Different therapeutic purposes can be achieved by loading different types of drugs such as antibiotics, bioactive factors, etc.In this review, different types of in situ gel with temperature-sensitive, ion-sensitive, pH-sensitive and solvent-exchanged characteristics were introduced for their applications and limitations in the delivery of drug for periodontitis;and the elimination of periodontal inflammation, periodontal tissue repair and the long-term role after loading microsphere achieved by the in situ gel system were also reviewed.