儿童中药制剂常用剂型及共性技术应用研究现状及思考

目前儿童中药制剂剂型选择、辅料优选、工艺设计、包装装置等成人化倾向比较普遍, 导致给药剂量不准、患儿用药顺应性差, 药物有效性和安全性难以保证, 药品不良反应事件频发。因此, 研究开发符合儿童用药特点的制剂, 突破儿童制剂关键技术迫在眉睫。分析了口服液、糖浆剂、颗粒剂等常用剂型, 探讨其在儿童中药制剂中的应用情况, 并针对儿童中药制剂中存在的药物溶解度低、服用口感差、给药剂量不准确等问题, 探讨增溶、掩味和定量给药等共性技术的特点及应用, 以期为儿童中药制剂的研发奠定基础并提供依据。 

Review on the Application of Common Formulations and Generic Techniques of Children's Chinese Medicine Preparations

Currently, adultification phenomenon in formulation selection, excipient optimization, process design, package equipment of children's Chinese medicine preparations are common, resulting in inaccurate dosage, poor medication compliance, difficulties in ensurance of drug's effectiveness and safety, as well as frequent adverse drug reactions. Therefore, it is urgent to investigate the preparations that conform to the characteristics of children's medication and break through the key technologies of children's preparations. This article analyzes the oral liquid, syrup, granule and other dosage forms, meanwhile discusses their application in Chinese medicine preparations for children. At the same time, on the issues of low solubility, poor taste and inaccurate dosage in children's Chinese medicine preparations, the characteristics and utilization of generic technologies such as solubility enhancement, taste masking and quantitative administration are discussed. The review aims to lay a foundation and provide a basis for the research and development of children's Chinese medicine preparations.