| 油酸诱导慢性胰腺炎大鼠肝脏细胞IR及IRS-1蛋白表达的改变 |
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| 引用本文： | 赵战朝,邱轶伟,梁泉,袁咏,薛承锐.油酸诱导慢性胰腺炎大鼠肝脏细胞IR及IRS-1蛋白表达的改变[J].天津医科大学学报,2007,13(3):373-375. |
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| 作者姓名： | 赵战朝 邱轶伟 梁泉 袁咏 薛承锐 |
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| 作者单位： | 天津医科大学总医院中西医结合外科,天津,300052 |
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| 摘 要： | 目的:观察慢性胰腺炎(CP)模型大鼠肝脏胰岛素受体(IR),胰岛素受体底物-1(IRS-1)蛋白表达的改变,探讨慢性胰腺炎继发性糖代谢异常的可能机制。方法:将用油酸诱导的CP大鼠作为模型组,同法注入生理盐水的大鼠为对照组,Western blot法测定各组大鼠肝细胞IR,IRS-1蛋白表达的改变。结果:模型组IR,IRS-1蛋白的表达较对照组都有明显降低(P<0.05)。结论:胰岛素信号转导异常可能参与了CP继发糖代谢异常的机制。
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| 关 键 词： | 慢性胰腺炎 蛋白印记 胰岛素受体 胰岛素信号转导 大鼠 |
| 文章编号： | 1006-8147（2007）03-0373-03 |
| 收稿时间： | 2007-03-09 |
| 修稿时间： | 2007年3月9日 |
Protein expression of insulin receptor, insulin receptor substrate 1 of hepatic cell in experimental chronic pancreatitis rat induced by oleic acid |
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| ZHAO Zhan-chao,QIU Yi-wei,LIANG Quan,YUAN Yong,XUE Cheng-rui.Protein expression of insulin receptor, insulin receptor substrate 1 of hepatic cell in experimental chronic pancreatitis rat induced by oleic acid[J].Journal of Tianjin Medical University,2007,13(3):373-375. |
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| Authors: | ZHAO Zhan-chao QIU Yi-wei LIANG Quan YUAN Yong XUE Cheng-rui |
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| Affiliation: | Department of Integration of Traditional Chinese Medicine and West Medicine Surgery, General Hospital, Tianjin Medical University, Tianjin 300052, China |
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| Abstract: | Objective: To observe the changes of protein expression of insulin receptor,insulin receptor substrate 1 of hepatic cell of the model rat of chronic pancreatitis (CP) ,so as to discuss the mechanism of diabetes secondary to chronic pancreatitis. Methods: The experimental model of chronic pancreatitis was induced by retrograde injection of oleic acid into the pancreatic duct. Protein expression of IR ,IRS-1 was observed by western blot. Results: The model rats showed remarkable depression of IR,IRS-1 protein expression. Conclusion: Abnormality of insulin signal transduction may play a important role in the mechanism of metabolic of glucose in CP. |
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| Keywords: | Chronic pancreatitis Western blot IR IRS-1 Insulin signal transduction Rat |
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