预混胰岛素30 R三次注射的有效性及安全性

①目的观察预混胰岛素30 R(诺和灵30 R)三次注射的有效性及安全性.②方法选择每天注射两次诺和灵30 R,而空腹血糖(FBG)仍控制不良的2型糖尿病病人56例,在此基础上睡前加用一次诺和灵30 R.同时睡前加餐,观察FBG、早餐后2 h血糖(PBG-2 h)、体质量及低血糖事件发生率.另选每天4次注射胰岛素(诺和灵R三餐前+诺和灵N睡前)强化治疗的2型糖尿病病人30例.比较每天三次预混胰岛素注射与四次胰岛素注射的总胰岛素用量,病人血糖、体质量变化、低血糖事件发生率及依从性.③结果诺和灵30 R三次注射后,FBG、PBG-2 h均显著下降(t=23.679、14.929,P<0.01);与每日四次胰岛素注射相比,在FBG水平相同情况下,日胰岛素总量及体质量无明显差异,低血糖事件发生率及依从性有优于后者的趋势,但无统计学意义.④结论预混胰岛素每日三次注射,能有效降低空腹及餐后血糖,且安全性和依从性良好.

SAFETY AND EFFICACY OF THREE-INJECTION OF PREMIXED INSULIN 30 R

Objective To observe the safety and efficacy of 3 injection of premixed insulin 30 R(Novolin 30 R). Methods Fifty six patients with type 2 diabetes, who had undergone 2 injection daily with premixed insulin 30 R with poor control of the fasting blood glucose(FBG), were selected. The patients were given food and an additional injection of Novolin 30 R before going to bed. FBG, glucose at two hours after breakfast, body weight, and incidence of hypoglycemia were observed. Another 30 patients with type 2 diabetes receiving reinforcing therapy of four injections daily were selected. The overall dose of insulin, the changes of blood sugar and body weight, the incidence of hypoglycemia, and compliance were compared between the two groups. Results Both FBG and blood sugar after breakfast decreased in the 3 injection group ( t=23.679,14.929; P <0.01). At the same FBG level, the total doses of daily insulin and weight of the patients in the 3 injection group were not significantly different from those of the 4 injection group. The incidence of hypoglycemia and the hypoglycemic affairs and compliance in the 3 injection group were both superior to those in the 4 injection group, but with no statistical significance. Conclusion Three injections of premixed insulin 30 R daily is safe and compliant to decrease effectively FBG and blood sugar level after breakfast.