| 胃癌组织幽门螺杆菌感染与微卫星不稳定性研究 |
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| 引用本文： | 房殿春,周晓东,罗元辉,鲁荣,刘为纹.胃癌组织幽门螺杆菌感染与微卫星不稳定性研究[J].第三军医大学学报,1999,21(10):699-701. |
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| 作者姓名： | 房殿春 周晓东 罗元辉 鲁荣 刘为纹 |
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| 作者单位： | 第三军医大学附属西南医院消化内科,重庆,400038 |
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| 基金项目： | 国家自然科学基金!39670347 |
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| 摘 要： | 通过分析胃癌组织幽门螺杆菌感染与微卫星ＤＮＡ不稳定性（ＭＳＩ）的关系，探讨幽门螺杆菌与胃癌发生中的作用。方法：采用ＰＣＲ为基础的方法对４９例胃癌组织Ｈｐ尿素酶酶和Ｂ基因以及６个微卫星位点（Ｄ１７ｓ２６１，Ｄ１７ｓ７９９，ＴＣＦ－２，Ｄ１８ｓ３４，Ｄ５ｓ４０９和Ｄ５ｓ４０９和Ｄ５ｓ８２）进行检测，对Ｈｐ感染与微卫星不稳定性间的关系进行分析，结果胃癌组织ＨｐＤＮＡ的检出率为４０．８％（２０／４９），其
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| 关 键 词： | 肿瘤/病因学 幽门螺杆菌 微卫星不稳定性 |
The relationship of Helicobacter pylori infection with microsatelliate instability in gastric cancer |
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| Fang Dianchun,Zhou Xiaodong,Luo Yuanhui,Lu Rong,Liu Weiwen.The relationship of Helicobacter pylori infection with microsatelliate instability in gastric cancer[J].Acta Academiae Medicinae Militaris Tertiae,1999,21(10):699-701. |
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| Authors: | Fang Dianchun Zhou Xiaodong Luo Yuanhui Lu Rong Liu Weiwen |
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| Abstract: | Objective:To evaluate the role of Helicobactor Pylori (Hp) in the development of gastric cancer. Mehtods: The urease genes A and B of Hp and rnicrosatellite instability (MSI ) at loci D17s261,D17s799, TCF-2, D18s34, D5s409 and D5s82 were examined with PCR-based technique. The relationship of Hp infecti0n with MSI was analyzed. Results: Hp DNA was found in 40. 8% (20/49) of the cases of gastric cancer ancl MSI detected in 22. 4 % (11/49) at D17s261, 22. 4 % (11/49) at D 17s799, 18. 4 % (9/49) at TCF-2and 28. 6% (14/49) at D5s82. No significant difference was found in the frequency of MSI between Hp positive and Hp negative cases (PX0. 05). Conclusion: Hp infection showed no association with MSI and may exert indirect effect on the developrnent of gastric cancer. |
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| Keywords: | gastric cancer/etiology H pylori microsatellite instability |
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