| 不同生物学行为非小细胞肺癌组织中ZNF266基因的差异表达及意义 |
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| 引用本文： | 赵晓龙,葛明建,黎力.不同生物学行为非小细胞肺癌组织中ZNF266基因的差异表达及意义[J].第三军医大学学报,2011,33(12). |
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| 作者姓名： | 赵晓龙 葛明建 黎力 |
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| 作者单位： | 重庆医科大学附属第一医院胸心外科,重庆,400016 |
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| 基金项目： | 国家自然科学基金(30972961); 重庆市自然科学基金(CSCT2008BB5210)~~ |
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| 摘 要： | 目的观察zinc finger protein 266(ZNF266)基因在不同生物学行为非小细胞肺癌(non-small cell lung carci-noma,NSCLC)组织中的表达水平并探讨其在NSCLC发生、发展及淋巴结转移中的意义。方法选取30例不伴有淋巴结转移的NSCLC原发灶及癌旁正常组织标本和30例伴有淋巴结转移的NSCLC原发灶及淋巴结转移灶标本,采用SABC免疫组织化学三步法检测各组标本中ZNF266基因的蛋白表达水平。结果 ZNF266蛋白表达在NSCLC组织中阳性表达率显著高于癌旁正常肺组织(40%vs 7%,P<0.01);在伴有淋巴结转移的原发灶中的表达明显高于不伴有淋巴结转移的原发灶(67%vs 40%,P<0.05);淋巴结转移灶中ZNF蛋白表达水平明显高于原发灶(93%vs 40%,P<0.05)。结论 ZNF266基因可能参与了NSCLC的发生、发展及淋巴结转移。
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| 关 键 词： | 癌 非小细胞肺 锌指 肿瘤转移 免疫组织化学 |
Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance |
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| Zhao Xiaolong,Ge Mingjian,Li Li.Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(12). |
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| Authors: | Zhao Xiaolong Ge Mingjian Li Li |
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| Affiliation: | Zhao Xiaolong,Ge Mingjian,Li Li(Department of Cardiothoracic Surgery,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016,China) |
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| Abstract: | Objective To study the significance of occurrence,development and lymphatic metastasis of non-small cell lung carcinoma(NSCLC) by observing the expression level of zinc finger protein 266(ZNF266) in NSCLC tissue with differential biological behaviors.Methods Expression levels of ZNF266 in 30 samples of primary NSCLC tissue without lymphatic metastasis and its adjacent normal tissue,and in 30 samples of primary NSCLC tissue with lymphatic metastasis,were measured with the 3-step SABC immunohistochemistry met... |
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| Keywords: | carcinoma non-small cell lung zinc fingers neoplasm metastasis immunohistochemistry |
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