Effect of herbal tonic on the membrane fluidity of the mice suffered from lymphatic leukemia

By using fluorescence polarization technology, the authors have studied variations in the membrane fluidity of red blood cell and spleen lymphocytes of the mice with lymphatic leukemia (L7212) untreated or treated by the compound tonic of traditional Chinese medicine decoction of reinforcing Qi and nourishing Yin and decoction of reinforcing Qi and nourishing blood. It was not only confirmed that the membrane fluidity of malignant lymphocytes increased more greatly, but also discovered that the variations could appear in early period of leukemia. The membrane fluidity of lymphocytes of the mice with leukemia treated by the herbal tonic could drop to normal level. But the membrane fluidity of the red blood cell between the normal mice (615) and the leukemia mice (L7212), untreated or treated by the herbal tonic, had no significant difference. Result: the above mentioned suggests the herbal tonic could resist leukemia by reducing the membrane fluidity of the lymphocytes and improving structure and function of the membrane.