云南省3551例先心病患者的ABO血型及性别分析

目的 分析云南地区先心病患者及正常个体的ABO血型分布,了解先心病与血型和性别的关系.方法 收集云南省昆明市延安医院2007年3月至2011年3月入院的先心病患者的病历资料,统计3 551名患者的ABO血型和性别的百分比,并分别与已经公布的2007年云南省人口血型分布和2005年云南人口性别分布进行对比.同时统计各种常见类型的先天性心脏病患者的ABO血型、性别分布情况,并进行统计学处理.结果 先天性心脏病患者的ABO血型分布与正常人的存在统计学差异(P＜0.05);不同类型的先天性心脏病患者间的血型无统计学意义(P＞0.05).先天性心脏病患者的性别分布与正常人的存在统计学差异(P＜0.05);不同类型的先天性心脏病患者之间的性别分布也有统计学意义(P＜0.05).结论 ABO血型与先天性心脏病的发生有关,A型和AB型患先天性心脏病的频率较高,血型因素可能是先天性心脏病的易患因素,但与发生何种类型的先天性心脏病无明显关系.性别与先天性心脏病的发生也可能有一定联系,女性较易患先天性心脏病,性别对患何种先天性心脏病也有影响.

Analysis of the ABO Blood Type and Sex Distributions of Patients with Congenital Heart Disease in Yunnan Province

Objective To investigate the association between congenital heart disease and ABO blood types as well as sex by analyzing the distribution of the blood type and sex both in patients with congenital heart disease and healthy controls in Yunnan province.Methods We used case-control study(case=3 551) method,cases were analysed by blood type,sex and other conditions of hospitalized patients with congenital heart disease from March,2007 to March,2011 in Kunming Yan’an Hospital,Yunnan Province.And controls were using the announced population data in Yunnan Province.We calculated the percentage of the ABO blood type and gender,and compared them with the announced blood distribution of population in 2007,Yunnan Province and gender distribution of population in 2005,Yunnan Province.In addition,we analyzed ABO blood type and gender distributions of patients with various common types of congenital heart disease and used Chi-square test for statistic analysis.Results There was a significant difference in ABO blood type distribution between patients with congenital heart disease and controls(P<0.05),but no difference among various types of congenital heart disease(P>0.05).In addition,there were significant differences in gender distribution between patients and normal people(P<00.05),and also significant differences among various types of congenital heart disease(P<00.05).Conclusions Blood type and gender do contribute to congenital heart disease.Blood types of A or AB may be a higher risk factor of CHD,but can’t affect the occurrence of different types of congenital heart disease.Besides,we found the gender "female"is a risk factor for CHD susceptibility.