| HBV前S_2蛋白检测的临床意义 |
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| 引用本文： | 邬质彬,苏朝康,徐国城,钟世聪.HBV前S_2蛋白检测的临床意义[J].广西医科大学学报,1990(3). |
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| 作者姓名： | 邬质彬 苏朝康 徐国城 钟世聪 |
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| 作者单位： | 广西医学院流行病学教研室，广西医学院流行病学教研室，广西医学院流行病学教研室，广西医学院附院传染病科 |
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| 摘 要： | 采用单克隆抗preS_2RPHA法检测HBV所致各型肝炎的preS_2,检出率为:急肝86.6%、慢迁肝81.2%、慢活肝87.5%、肝硬化83.3%、肝癌80%、HBsAg携带者73.3%,健康人为0。此结果与国内文献报道相似。证明preS_2检出在HBsAg携带者中低于各型肝炎。preS_2检出与HBeAg阳性检出呈正相关。在慢肝中检出preS_2,提示preS_2可作为观察病毒复制和预后的指标之一。
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| 关 键 词： | 乙型肝炎病毒前蛋白S_2 单克隆抗pre S_2 蛋白 R-PHA |
CLINICAL SIGNIFICANCE OF DETERMINING HBV PRE S2 |
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| Guangxi Medical College Wu Zhibin,et al.CLINICAL SIGNIFICANCE OF DETERMINING HBV PRE S2[J].Journal of Guangxi Medical University,1990(3). |
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| Authors: | Guangxi Medical College Wu Zhibin |
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| Abstract: | Serum preS_2 were measured by monoclonal antibody R-PHA of anti-preS_2 in patients with several clinical types of hepatitis B.The positive rates of preS_2 in AH,CAH,CPH,CH,PHC,HC and healthy man were 86.6%,81.2%,87.5%,83.3%,80.0%,73.3% and 0% respectively;the highest were those of CAH and AH.The positive rates of HBeAg in preS_2 positive patients and preS_2 negative patients were 76.4% and 0% respecti- vely.These results revealed that there was a direct relationship between the positive rate of preS_2 and the positive rate of HBeAg.The positive rate of preS_2 in HBsAg carriers was lower than those of the several clinical types of hepatitis B.These results suggested that preS_2 test could be used as markers for evaluating the chronic evolution,HBV replication and the prognosis of hepatitis. |
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| Keywords: | HBV preS_2 anti-preS_2 of monoclon R-PHA |
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