肾康注射液联合青霉素与替米沙坦治疗肾小球肾炎合并急性间质性肾炎患者的效果

目的:观察肾康注射液联合青霉素与替米沙坦治疗肾小球肾炎合并急性间质性肾炎患者的效果。方法:选取134例肾小球肾炎合并急性间质性肾炎患者为研究对象,按随机数字表法将其分成观察组与对照组各67例。对照组给予青霉素联合替米沙坦治疗,观察组在对照组基础上加用肾康注射液治疗,比较两组临床疗效、治疗前后肾功能指标血管内皮生长因子(VEGF)、胱抑素C(CysC)、单核细胞趋化蛋白-1(MCP-1)]水平和不良反应发生率。结果:观察组治疗总有效率为97.01%(65/67),明显高于对照组的85.07%(57/67),差异有统计学意义(P<0.05);治疗后,观察组VEGF、CysC和MCP-1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肾康注射液联合青霉素与替米沙坦治疗肾小球肾炎合并急性间质性肾炎患者可提高治疗总有效率,降低肾功能指标水平,其效果优于青霉素联合替米沙坦治疗。

Effects of Shenkang injection combined with Penicillin and Telmisartan in treatment of patients with glomerulonephritis and acute interstitial nephritis

Objective:To observe effects of Shenkang injection combined with Penicillin and Telmisartan in treatment of patients with glomerulonephritis and acute interstitial nephritis.Methods:134 patients with glomerulonephritis and acute interstitial nephritis were selected as the research objects,and were divided into observation group and control group according to the random number table method,67 cases in each.The control group was treated with Penicillin combined with Telmisartan,while the observation group was treated with Shenkang injection on the basis of those of the control group.The clinical efficacy,the renal function index levelsvascular endothelial growth factor(VEGF),cystatin C(CysC)and monocyte chemotactic protein-1(MCP-1)]levels before and after the treatment and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.01%(65/67),which was significantly higher than 85.07%(57/67)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of VEGF,CysC and MCP-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Shenkang injection combined with Penicillin and Telmisartan can improve the total effective rate of treatment of the patients with glomerulonephritis and acute interstitial nephritis,and reduce the levels of renal function indexes.Moreover,it is superior to Penicillin combined with Telmisartan treatment.