头孢曲松钠与头孢克肟序贯治疗下呼吸道感染患儿的效果

目的:观察头孢曲松钠与头孢克肟序贯治疗下呼吸道感染患儿的效果。方法:选取312例下呼吸道感染患儿为研究对象,按照随机数字表法分为对照组和观察组各156例。两组均接受常规治疗,在此基础上,对照组采用头孢曲松钠治疗,观察组采用头孢曲松钠与头孢克肟序贯治疗。比较两组临床疗效、症状消失时间(咳嗽消失时间、退热时间、肺啰音消失时间)、治疗前后血清炎性因子C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子-α(TNF-α)]水平和不良反应发生率。结果:观察组治疗总有效率为98.72%(154/156),高于对照组的94.23%(147/156),差异有统计学意义(P<0.05);观察组咳嗽消失时间、退热时间和肺啰音消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清CRP、IL-6和TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:头孢曲松钠与头孢克肟序贯治疗下呼吸道感染患儿,可提高治疗总有效率,缩短症状消失时间,以及降低血清炎性因子水平,效果优于单纯头孢曲松钠治疗。

Effects of Ceftriaxone sodium and Cefixime sequential therapy in children with lower respiratory tract infections

Objective:To observe effects of Ceftriaxone sodium and Cefixime sequential therapy in children with lower respiratory tract infections.Methods:312 children with lower respiratory tract infections were selected as the research objects,and were divided into control group and observation group according to the random number table method,with 156 cases in each group.Both groups received conventional treatment.On this basis,the control group was treated with Ceftriaxone sodium,while the observation group was given the Ceftriaxone sodium and Cefixime sequential therapy.The clinical efficacy,the symptom disappearance time(cough disappearance time,fever clearance time,pulmonary rales disappearance time),the serum inflammatory factor levelsC-reactive protein(CRP),interleukin-6(IL-6),tumors cell necrosis factor-alpha(TNF-α)]and the incidence of adverse reactions before and after the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 98.72%(154/156),which was higher than 94.23%(147/156)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of cough,fever and pulmonary rales in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the serum CRP,IL-6 and TNF-αlevels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ceftriaxone sodium and Cefixime sequential therapy in the children with lower respiratory tract infections can increase the total effective rate of treatment,shorten the symptom disappearance time,and reduce the serum inflammatory factor levels.Moreover,it is superior to single Ceftriaxone sodium treatment.