| 灯盏花素联合氯沙坦治疗早期糖尿病肾病的临床观察 |
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| 引用本文： | 蒋宇峰,何立群,沈丽萍.灯盏花素联合氯沙坦治疗早期糖尿病肾病的临床观察[J].辽宁中医药大学学报,2010(4). |
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| 作者姓名： | 蒋宇峰 何立群 沈丽萍 |
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| 作者单位： | 上海中医药大学附属曙光医院肾内科;肝肾疾病病证教育部重点实验室;上海市高校中医内科E-研究院;上海市杨浦区中医院; |
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| 基金项目： | 上海市教育委员会E-研究院建设计划资助项目(E03008);;上海高校创新团队建设资助项目 |
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| 摘 要： | 目的:观察灯盏花素与氯沙坦联合治疗早期糖尿病肾病的疗效。方法:将80例糖尿病肾病患者随机分为治疗组42例和对照组38例,两组均予常规治疗,氯沙坦口服每次100mg,每日1次,治疗组另予灯盏花素40mg,加入生理盐水250mL,静脉滴注共两个疗程。观察两组临床症状,尿微量白蛋白排泄率(UAER),尿B2-微球蛋白(B2-MG),纤维蛋白原(FIB),D-二聚体(D-D)指标变化。结果:治疗组总有效率76.2%,对照组总有效率44.2%,两组比较有统计学差异(P<0.05)。治疗后两组UAER,尿B2-MG均有所下降,与治疗前比较差异有统计学意义(P<0.05);且治疗组与对照组比较,差异有统计学意义(P<0.05);治疗后治疗组FIB,D-D显著下降,与治疗前及对照组比较,差异有统计学意义(P<0.05),对照组治疗前后差异无统计学意义(P>0.05)。结论:灯盏花素与氯沙坦联合治疗早期糖尿病肾病有明显疗效。
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| 关 键 词： | 灯盏花素 氯沙坦 糖尿病肾病 |
Clinical Observation on Therapeutic Effects of Combined Use of Dengzhanhuasu and Losartan in Treating Early Diabetic Nephropathy |
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| JIANG Yu-feng,HE Li-qun,SHEN Li-ping.Clinical Observation on Therapeutic Effects of Combined Use of Dengzhanhuasu and Losartan in Treating Early Diabetic Nephropathy[J].Journal of Liaoning University of Traditional Chinese Medicine,2010(4). |
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| Authors: | JIANG Yu-feng HE Li-qun SHEN Li-ping |
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| Affiliation: | 1.Department of Nephrology/a>;the Affiliated Shuguang Hospital of Shanghai University of Chinese Medicine/a>;Shanghai 200021/a>;China/a>;2.E-Institute of Internal Chinese Medicine in Shanghai University/a>;3.Shanghai Yangpu District Chinese Medical Hospital/a>;Shanghai 200041/a>;China |
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| Abstract: | Objective:To observe the clinical effects of combined use of dengzhanhuasu and losartan in treating early diabetic nephropathy(DN).Methods:Eighty patients with DN were randomly assigned to the theatment group 42cases and the control group 38 cases.Conventional treatment was given to both groups,but to the control group 100 mg losartan was given orally once a day additionally,while to the treatment group the same dosage of losartan po.and 40mg/d of dengzhanhuasu injection by adding in 250mL 0.9% normal salin... |
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| Keywords: | Dengzhanhuasu losartan diabetic nephropathy |
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