医院和社区获得性金黄色葡萄球菌耐药性情况调查

目的 了解临床分离的社区获得性和医院获得性金黄色葡萄球菌的耐药情况,为进一步指导临床治疗,更好地控制MRSA引起的感染提供依据.方法 采用K-B纸片扩散法检测金黄色葡萄球菌对不同种类抗生素的敏感性.结果 医院获得性甲氧西林敏感金黄色葡萄球菌(HA-MSSA)对头孢唑啉、庆大霉素和左氧氟沙星的耐药率显著高于社区获得性甲氧西林敏感金黄色葡萄球菌( CA-MSSA) (P＜0.05)；医院获得性耐甲氧西林金黄色葡萄球菌( HA-MRSA)对头孢唑啉、红霉素、克林霉素、四环素、庆大霉素、左氧氟沙星和利福平的耐药率显著高于CA-MSSA和HA- MSSA( P＜0.05);HA- MRSA多重耐药菌株所占的比率为90.4％,显著高于CA-MSSA的20.0％和HA-MSSA的37.4％,差异均有统计学意义(P＜0.05).结论 医院获得性金黄色葡萄球菌耐药情况较严重,CA-MSSA和HA-MSSA药物敏感性明显高HA-MRSA,HA-MRSA呈现多重耐药性.

Study of drug resistance of hospital and community acquired Staphylococcus aureus

Objective To analyze the drug resistance of hospital and community acquired Staphylococcus aureus.Method The antimicrobial sensitivity tests of Staphylococcus aureus were tested by Kirby-Bauer method.Results The resistance rates to cefazolin,gentamicin and levofloxacin of hospital-acquired methicillin-sensitive Staphylococcus aureus(HA-MSSA) were higher than those of community-acquired methicillin-sensitive Staphylococcus aureus(CA-MSSA)(P< 0.05).The resistance rates to cefazolin,erythromycin,clindamicin, tetracycline,gentamicin,levofloxacin and rifampin of hospital-acquired methicillin-resistant Staphylococcus aureus(HA-MRSA) were higher than those of CA-MSSA and HA-MSSA(P<0.05).Conclusions CA-MSSA and HA-MSSA were more sensitive to all antibiotics than HA-MRSA.MRSA shows general resistance to many kinds of antibiotic drugs.