华支睾吸虫病流行区流行病学研究

目的 为了解广州市番禺区华支睾吸虫流行情况，于2000年6月～2002年10月在番禺沙湾镇的紫坭村和石基镇的前锋村开展了华支睾吸虫病流行病学调查。方法 采用改良加藤氏厚涂片法粪便检查人群华支睾吸虫卵；华支睾吸虫感染静脉采血作转氨酶、乙肝表面抗原、核心抗体检测和腹部B超检查；开展中间宿主和保虫宿主调查。结果 华支睾吸虫总感染率13．7％。其中紫坭村感染率18．2％；前锋村感染率8．O％；男性感染率为22．3％，女性感染率为6．6％，以20～50岁年龄组最高。华支睾吸虫感染HBsAg阳性率为20．9％，HBeAb阳性率为40．3％；42．4％感染出现不同的肝胆道病变；在当地鱼塘的鱼苗中找到华支睾吸虫囊蚴；解剖当地犬、猫中，均发现华支睾吸虫成虫。结论 番禺区是华支睾吸虫重点流行区之一，且华支睾吸虫已对当地群众的身体健康造成了严重危害。

An Epidemiology Study on Clonorchis sinensis Disease at an Endemic Area of China

Objective To study the epidemic situation of Clonorchis sinensis in Panyu district of Guangzhou city of China. Methods An epidemiology investigation for Clonorchis sinensis was carried out in June, 2000 to October, 2002 at two village of Panyu district of Guangzhou city. Clonorchis sinensis eggs in ejecta of population were detected by kato katy thick smear method. Blood samples of Clonorchis sinensis infected individuals were analyzed for hepatic biochemistry index, such as ALT, HBsAg and HBcAb, etc. And the investigation to intermediate and reservoir hosts had also been carried out. Results The total infective rate of Clonorchis sinensis in the local area was 13.7%. That infection rates of Zini village and Qianfang village were 18.2%and 8.0%respectively. And the male and female infective rate were 22.3%and 6.6%respectively. The infection rate of 20-50 age group was higher than others. The positive rate with HBsAg in Clonorchis sinensis infected individuals was 20.9%and that with HBcAb was 40.3%. 42.4%infected people showed hepatic and bile duct pathological changes. Clonorchis sinensis larval was discovered in the fry of the local fish pools. Clonorchis sinensis imago was found in the local dogs and cats in the autopsy. Conclusion Clonorchis sinensis was endemic in the two villages of Panyu district of Guangzhou city, and cause health problems in the local populations.