宣肺布津颗粒及其拆方组对干燥综合征模型鼠干预研究

目的：探讨宣肺布津颗粒全方组及其各拆方组对干燥综合征（Sjogren＇s Syndrome,SS）模型鼠饮水量、血清TNF-α、Fas表达的影响。方法：将实验大鼠80只随机分为10组：开肺组、润肺组、清肺组、开肺＋润肺组、开肺＋清肺组、润肺＋清肺组、宣肺布津颗粒组、必嗽平对照组、干燥综合征模型组、空白对照组,造模2周后,治疗组开始灌胃给药,模型组与空白对照组给予等体积的生理盐水,给药6周后眼眶后取血检测TNF-α、Fas含量,实验期间观察各组大鼠饮水量的变化。结果：宣肺布津颗粒组对干燥综合征模型大鼠饮水量、TNF-α、Fas表达的影响比各拆方组作用更明显,效果更好。结论：宣肺布津颗粒有明显抑制淋巴细胞浸润、改善唾液腺分泌功能的作用,其治疗SS的作用机理可能与抑制免疫炎症,抑制血清TNF-α、Fas的表达有关。

Experimental Research of Xuanfei Bujing Grain and Resolve Groups on the SS Mice Model

Objective：To explore the effect of the whole and resolve groups of Xuanfei Bujing grain to the lever of the consumption of water and serum TNF-α,Fas for SS model mices.Method：80 experimental mices were randomly divided into 10 groups：open lung group,moist lung group,clear lung group,open and moist lung group,open and clear lung group,moist and clear lung group,Xuanfei Bujing grain brombexine hydrochloride group,SS model group and blank comparison group.After making the models of 2 weeks,treating groups were given drugs to stomach,model and blank groups were given the same volume normal saline.During the experiment,observing the change of the consumption of water for each mices groups and examining the lever of TNF-α,Fas by taking blood from eye socket after 6 weeks.Results：Compared with resolve groups,Xuanfei Bujing grain group has obvious effect for the consumption of water and the lever of TNF-α,Fas of SS model mices.Conclusion：SS model mices obviously inhibit the soakage of lymphocyte and improve the secretion function of salivary glands.Its treatment mechanism may be inhibiting immunological inflammation and the lever of TNF-α,Fas.