中性粒细胞单核细胞乘积联合血肌酐诊断急性胰腺炎严重程度的价值

目的 探讨中性粒细胞单核细胞乘积(NMP)联合血肌酐判断急性胰腺炎严重程度的能力.方法 回顾性分析120例维吾尔族急性胰腺炎患者临床资料,分非重症急性胰腺炎和重症急性胰腺炎两组.比较两组一般资料,评估NMP联合血肌酐与住ICU、住院死亡的相关性,通过ROC曲线下面积比较急性生理学和慢性健康评分Ⅱ、中性粒细胞淋巴细胞比值、NMP联合血肌酐判断急性胰腺炎严重程度的能力.结果 入院24 h内NMP、血肌酐水平重症急性胰腺炎组均高于非重症急性胰腺炎组(P＜0.001);NMP联合血肌酐与住ICU、住院死亡均呈正相关(r=0.489,P＜0.001;r=0.383,P＜0.001);急性生理学和慢性健康评分Ⅱ与NMP联合血肌酐的ROC曲线下面积差异无统计学意义(Z=0.38,P=0.704),且均优于中性粒细胞淋巴细胞比值(Z=3.10,P=0.002;Z=2.43,P=0.016).结论 NMP联合血肌酐可作为判断急性胰腺炎严重程度的一种简单而有效方法.

Value of neutrophil-monocyte product combined with serum creatinine in assessing the severity of acute pancreatitis

Objective To investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP).Methods The clinical data of 120 Uighur patients with AP were retrospectively analyzed,including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group).The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed.The receiver operating characteristic (ROC) curves were plotted to compare the efficiency of acute physiology and chronic health evaluation (APACHE-Ⅱ),neutrophil-lymphocyte ratio (NLR) and NMP combined with Scr in determining the severity of AP.Results The levels of NMP and Scr were significantly higher in SAP group than in non-SAP group within 24 h after admission (P=0.012;P＜ 0.001).NMP combined with Scr was positively correlated with ICU admission (r=0.489,P＜0.001) and in-hospital death (r=0.383,P＜0.001).No significant difference was found in the area under curve (AUC) between APACHE-Ⅱ and NMP combined with Scr for determining AP severity (Z=0.38,P=0.704),but they both were superior to NLR (Z=3.10,P=0.002;Z=2.43,P=0.016).Conclusion NMP combined with Scr can be a simple and effective indicator for determining the severity of AP.