苦参素注射液治疗慢性乙型肝炎临床疗效分析

对33例新生儿高胆红素血症光疗前后的水钠代谢及血浆抗利尿激素（ADH）、血清醛固酮（ALD）浓度的变化进行了观测。结果显示：光疗期水钠代谢均有增加，入液量9．63ml／（kg．h），入纳量0．0651mmol／（kg.h）．光疗期血浆ADH浓度无显著变化，血清ALD浓度则有下降．

Clinical efficacy of kurorinone in the treatment of chronic hepatitis B

To investigate the effectiveness of kurorinone injection in the treatment of patientswith chronic hepatitis B. Methods: Sixty-four patients with chronic hepatitis B, consisting of 13 chronicpersistent hepatitis (CPH), 42 chronic active hepatitis (CAH) and 9 CAH with early liver cirrhosis (CAH+LC), were treated with kurorinone intramuscularly. Fifty-two cases of chronic hepatitis B treated with in-terferon-a(IFN-a) were used as c0ntr0l(8 CPH, 38 CAH and 6 CAH+LC)- Results: It was revealed thatthe elevated serum alanine amin0transferase (ALT) and bilirubin(SB) decreased t0 normal level at a rate 0f81. 6% and 69. 9% in kurorinone group, whi1e 73. 7 % and 64. 0% in IFN-a group(P>0. 05).The serumnegative-convertion rate of HBeAg and HBV DNA were 44, 4% and 45. 3% in kurorinone group, while48. 0% and 51. 9 % in IFN-a group (P>0. 05 ). Among kurorinone group, the serum negative-c0nvertionrate of HBeAg and HBVDNA were 61. 0% and 61. 9% in CAH cases, while 15. 4% and 15. 4% in CPHcases and 11. 1 % and 11.1 % in CAH+LC cases respectively (P<0. 05). No side effects were observed ex-cept for slight local pain. Conclusion: This study indicates that kurorinone may be promising in the treat-ment of chronic hepatitis B.