| 胆汁损伤胃黏膜的实验研究 |
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| 引用本文： | 宋银雪,龚均,吴建涛,耿娟.胆汁损伤胃黏膜的实验研究[J].南方医科大学学报,2008,28(7):1219-1222. |
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| 作者姓名： | 宋银雪 龚均 吴建涛 耿娟 |
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| 作者单位： | 西安交通大学附属第二医院消化科,陕西,西安,710004 |
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| 基金项目： | 卫生部临床学科重点项目 |
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| 摘 要： | 目的 通过大鼠实验模型探讨胆汁对胃黏膜的损伤作用.方法 SD大鼠分成4组:十二指肠胃反流(DGR)组、DGR 胆管结扎(BDL)组、BDL组、对照组.术后12周处死大鼠,观察胃黏膜损害及病理组织学改变,电子显微镜硝酸镧标记观察胃黏膜细胞间的紧密连接.结果 DGR组比去除胆汁的DGR出现胃黏膜的充血、小凹超常增生和黏膜细胞间的紧密连接受损程度严重.结论 在十二指肠胃反流所致胃黏膜的损伤中,去除胆汁可使胃黏膜的损伤减轻,胆汁是胃黏膜损伤的重要因素.
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| 关 键 词： | 胆汁反流 十二指肠胃反流 胃黏膜损伤 胆汁 胃黏膜损伤 实验模型 研究 reflux injury gastric bile 因素 严重 程度 增生 结果 紧密连接 细胞间 镧标记 硝酸 电子显微镜 组织学改变 病理 |
Role of bile in rat gastric mucosal injury due to duodenogastric reflux |
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| SONG Yin-xue,GONG Jun,WU Jian-tao,GENG Juan.Role of bile in rat gastric mucosal injury due to duodenogastric reflux[J].Journal of Southern Medical University,2008,28(7):1219-1222. |
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| Authors: | SONG Yin-xue GONG Jun WU Jian-tao GENG Juan |
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| Affiliation: | Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.E-mail: songyinxue@126.com. |
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| Abstract: | OBJECTIVE: To explore the effect of bile in inducing gastric mucosal injury in rats. METHODS:SD rats were divided into 4 groups, namely bile duct ligation group, duodenogastric reflux (DGR) group, DGR plus bile duct ligation group and normal control group. The pathological changes in the gastric mucosa and tight junction 3 months after gastrojejunostomy were observed and compared with the findings in the normal control rats. RESULTS: Compared with the rats in DGR plus bile duct ligation group, the rats in DGR group showed obvious gastric mucosal hyperemia, foveolar hyperplasia and severely impaired tight junction between the gastric mucosal cells. CONCLUSION: Bile plays an important role in gastric mucosal injury due to DGR. |
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| Keywords: | bile reflux duodenogastric reflux gastric mucosa |
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