基质诱导的自体软骨移植术后3T磁共振T2mapping成像对移植软骨的分层定量评价

目的评估磁共振T2mapping成像技术在基质诱导自体软骨移植（MACT）术后的定量分析价值。方法纳入6例膝关节
MACT术后患者（9处软骨损伤），分别在术后3月、6月及12月进行磁共振动态随访检查，测量软骨修复区与正常对照区深浅两
个区域及全层T2 值，横向比较同一时间点修复区与正常区T2 值差异，纵向评估术后3、6、12 个月修复区T2 值的变化。结果
MACT术后3、6月移植区全层T2值显著高于邻近正常软骨（P均<0.05），术后12月修复区全层T2值变化较正常对照区无明显
统计学差异（P=0.063）。术后6、12个月修复区浅层软骨T2值显著高于深层（P均<0.05）。术后3、6、12个月修复区深浅层T2值
纵向变化均有统计学差异（P均<0.05）。结论MACT术后磁共振T2mapping成像可作为评估关节软骨修复效果的重要依据。

3T magnetic resonance T2 mapping for evaluation of cartilage repair after matrix-associated autologous chondrocyte transplantation

Objective To assess the value of magnetic resonance imaging (MRI) T2 mapping in quantitative evaluation of
cartilage repair following matrix-associated autologous chondrocyte transplantation (MACT). Methods Six patients (with 9
plug cartilages) following MACT underwent MRI on a 3.0 Tesla MR scan system at 3, 6 and 12 months after the surgery. The
full-thickness and zonal areas (deep and superficial layers) T2 values were calculated for the repaired cartilage and control
cartilage. Results The mean T2 values of the repaired cartilage after MACT were significantly higher than that of the control
cartilages at 3 and 6 months (P<0.05), but not at 12 months (P=0.063). At 6 and 12 months, the T2 values of the superficial layers
were significantly higher than those of the deep layers in the repaired cartilages (P<0.05). The zonal (deep and superficial
layers) T2 values of the repaired cartilages decreased significantly over time at 6 and 12 months as compared to those at 3
months after the surgery (P<0.05). Conclusion MRI T2 mapping can serve as an important modality for assessing the repair of
the articular cartilage following MACT.