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决明子对糖尿病大鼠糖代谢、脂代谢的影响
引用本文:吴红,孙艳,吴琦,崔忠慧,何志鹏.决明子对糖尿病大鼠糖代谢、脂代谢的影响[J].牡丹江医学院学报,2006,27(2):6-8.
作者姓名:吴红  孙艳  吴琦  崔忠慧  何志鹏
作者单位:牡丹江医学院,157011
摘    要:目的:观察决明子水煎剂对糖尿病大鼠糖、脂代谢的影响.方法:链脲佐菌素(STZ) 诱导糖尿病大鼠模型, 将大鼠随机分为正常对照(C)、糖尿病组(DM)、决明子高剂量组、决明子中剂量组和决明子低剂量组.灌胃8周后检测血糖、糖化血红蛋白、血脂的变化.结果:与正常对照组大鼠比较,糖尿病组大鼠胆固醇、甘油三酯、低密度脂蛋白- 胆固醇明显增高( P < 0.01 , P < 0.05 , P <0.01) ,而高密度脂蛋白-胆固醇明显降低( P <0.05);决明子治疗组上述异常均明显减轻.糖尿病组大鼠血糖和糖化血红蛋白明显高于正常组(P <0.01) ,决明子治疗组较糖尿病组虽有所下降,但差异无显著性.结论:决明子水煎剂能有效纠正糖尿病大鼠脂代谢紊乱.

关 键 词:决明子  糖尿病  血糖  血脂
收稿时间:01 4 2006 12:00AM
修稿时间:2006年1月4日

EFFECT OF SEMEN CASSIAE ON GLUCOSE AND LIPID METABOLISM IN DIABETIC RATSE
Wu Hong et al..EFFECT OF SEMEN CASSIAE ON GLUCOSE AND LIPID METABOLISM IN DIABETIC RATSE[J].Journal of Mudanjiang Medical College,2006,27(2):6-8.
Authors:Wu Hong
Affiliation:Mudanjiang medical college 157011
Abstract:Objective:To observe the effect of Semen Cassiae on glucose and lipid metabolism in diabetic rats. Methods:Diabetic model was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats at a dose of 60mg/ kg bodyweight and then was randomly divided into five groups. Control groups ,DM groups and Semen Cassiae groups (low dosage ?middle dosage and high dosage group). After treated for eight weeks ,the levels of semen Cassiae serum total cholesterol ( TC) , triglyceride ( TG) , low density lipoprotein-cholesterol (LDL-C) ,high density lipoprotein-cholesterol (HDL-C) were evaluated. Results:The levels of serum TC ,TG,and LDL were all significantly increased in diabetic rats as compared with normal rats( P < 0. 01 , P < 0. 05 , P < 0. 01) , while the level of HDL was lower than that in normal group ( P < 0. 05) ; All these abnormalities were ameliorated when treated with semen Cassiae. there was some decline of them while treated with semen Cassiae as compared with group DM ,but had no significant discrepancy. Conclusion:Semen cassise can effectively correct the disorder of lipid metabolism in diabetic rats.
Keywords:diabetic mellitus  semen Cassiae  blood glucose  blood lipid
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