木香对家兔离体小肠平滑肌收缩的影响及机制研究

目的：分析木香对家兔离体小肠平滑肌收缩的影响,并探讨其作用机制.方法;用BL-420F生物机能实验系统记录小肠收缩力,观察木香对小肠的收缩作用;分析阻断α和β受体后,木香对小肠的收缩作用.结果：木香抑制小肠收缩,20 g/L的木香对小肠收缩幅度的抑制率达（44.88±1.38）％,对小肠收缩紧张性的抑制率达（29.68士2.36）％,差异有统计学意义（P＜0.05）,但不影响其收缩频率.阻断β受体,木香对小肠收缩的抑制作用消失;阻断α受体.木香抑制小肠收缩的作用没有明显改变.结论：木香抑制家兔离体小肠平滑肌收缩,其作用可能通过激活平滑肌β受体.

Effects of radix aucklandiae on contraction of rabbit intestine smooth muscle and its mechanism

Objective： To research the effects of radix aucklandiae on contraction of rabbit small intestine smooth muscles and its mechanism. Methods： The contraction curves of small intestine treated with or without radix aucklandiae were recorded with BL-420F biological signal recording system. Then a and β receptors were respectively blocked to explore their role in radix aucklandiae-mediated effect on contraction of small intestine. Results：Radix Aucklandiae inhibited intestinal contraction, when the Radix aucklandiae was 20 g/L ,the inhibition rate of contractile amplitude was （29.68±2.36） %, the inhibition rate of contraction tension was （29.68±2.36）%, the differences were statistically significant（P〈0.05）, but did not affect the frequency of contraction. Conclusion： Radix aucklandiae markedly inhibits the contraction of small intestine smooth muscle of rabbits via activation of β receptor.