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炎症状态下人牙周膜成纤维细胞中SLC7A11和GPX4的表达水平及其意义
引用本文:乔树伟,李保胜,李效宇,王子璇,李碧榕,董博,孟维艳.炎症状态下人牙周膜成纤维细胞中SLC7A11和GPX4的表达水平及其意义[J].吉林大学学报(医学版),2022,48(4):922-928.
作者姓名:乔树伟  李保胜  李效宇  王子璇  李碧榕  董博  孟维艳
作者单位:吉林大学口腔医院口腔种植科,吉林 长春 130021
基金项目:吉林省科技厅科技发展计划项目(20200404108YY)
摘    要:目的探讨在牙龈卟啉单胞菌脂多糖(P.g-LPS)刺激的炎症环境下,人牙周膜成纤维细胞(hPDLFs)中溶质载体家族7成员11(SLC7A11)和谷胱甘肽过氧化物酶4(GPX4)表达的变化,阐明P.g-LPS诱导牙周炎的可能机制。

关 键 词:牙龈卟啉单胞菌  脂多糖  人牙周膜成纤维细胞  溶质载体家族7成员11  谷胱甘肽过氧化物酶4  
收稿时间:2021-11-15

Expression levels of SLC7A11 and GPX4 in human periodontal ligament fibroblasts under inflammation and their significance
Shuwei QIAO,Baosheng LI,Xiaoyu LI,Zixuan WANG,Birong LI,Bo DONG,Weiyan MENG.Expression levels of SLC7A11 and GPX4 in human periodontal ligament fibroblasts under inflammation and their significance[J].Journal of Jilin University: Med Ed,2022,48(4):922-928.
Authors:Shuwei QIAO  Baosheng LI  Xiaoyu LI  Zixuan WANG  Birong LI  Bo DONG  Weiyan MENG
Affiliation:Department of Dental Implantology,Stomatology Hospital,Jilin University,Changchun 130021,China
Abstract:ObjectiveTo investigate the changes in the expressions of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in the human periodontal ligament fibroblasts(hPDLFs) under the inflammatory environment stimulated by Porphyromonas gingivalis lipopolysaccharide(P.g-LPS), and to clarify the possible mechanism of P.g-LPS in inducing periodontitis.
Keywords:Porphyromonas gingivalis  Lipopolysaccharide  Human periodontal ligament fibroblasts  Solute carrier family 7 member 11  Glutathione peroxidase 4  
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