低剂量电离辐射诱导免疫适应性反应的时间效应

本研究采用Ｘ线全身照射昆明系雄性小鼠模型，观察电离辐射诱导免疫适应性反应的预照射剂量（Ｄ１剂量，７５ｍＧｙ）及其后损伤性剂量（Ｄ２剂量，１．５～２．０Ｇｙ）的时间效应。结果表明，Ｄ１与Ｄ２时间间隔６～４８ｈ，Ｄ２照后１８～２４ｈ可诱导胸腺细胞自发增殖能力及脾细胞对丝裂原（ＣｏｎＡ和ＬｐＰＳ）反应性等适应性反应。

Time一effect relationship of immunological adaptive response induced by low doseX一 irradiation in mice

ln the present study, Kunming mice irradiated with whole一body X一rays were usedto observe time一effect relationship of immunological adaptive response induced by ionizing radiation.The results showed that preirradiation dose of 75 mGy X一rays with the intervals of 6一48 h betweenpre一irradiation and challenge irradiation could induce immunological adaptive response in the sponta-neous proliferation of thymocytes and the responses of splenocytes to Con A and LPS in mice at l8一24 h after challenge irradiation with l.5一2. 0 Gy X一rays.