白细胞介素-6在绝经后骨质疏松症发病机制中作用的临床研究

目的]探讨白细胞介素-6（IL-6）在绝经后骨质疏松症（PMOP）发病机制中的作用。方法]根据腰椎骨密度（BMD）扫描结果。将104例受试妇女分为3组。即绝经后骨质疏松组31例，绝经后非骨质疏松组37例，绝经前健康组36例，采用放兔法分别测定血清IL-6、雌二醇（E2）和骨钙素（BGP）水平。结果]绝经后妇女血清IL-6水平高于绝经前妇女，骨质疏松组又高于非骨质疏松组，以非骨质疏松组IL-6为因变量的多元回归分析显示；IL-6与BMD，E2呈负相关关系，与BGP呈正相关关系。与年龄无显著性相关关系。结论]绝经后骨质疏松症的骨丢失属高转换型，IL-6高表达与骨质疏松症发病以及雌激素减少有关。雌激素水平下降可导致IL-6分泌增多，从而刺激骨吸收，骨吸收超过骨形成导致骨质疏松的发生。

Effect of Interleukin-6 on the Pathogenesis of Postmenopausal Osteoporosis

Objective] To explore the effect of interleukin-6 (IL - 6) on the pathogenesis of postmenopausal osteoporosis (PMOP). Methods] According to the result of bone mineral density (BMD) scanning of lumbar vertebrae, 104 women were allocated to three groups. Thirty-one cases of PMOP was assigned to Group A, 37 postmenopausal women without osteoporosis to Group B and 36 healthy premenopausal women to Group C. Serum levels of IL-6, estrogen (E2) and bone gal protein (BGP) were determined by radioimmunoassay method. Results] Serum level of IL-6 was higher in Group A and Group B than that in Group C and higher in Group A than that in Group B. A multiple regression analysis in Group B showed that IL-6 level was correlated negatively with BMD and estrogen, positively with BGP and had no correlation with age. Conclusion] The pathogenesis of PMOP is related to the high level of IL-6 and the decrease of estrogen level.