麝香保心丸对冠心病患者血液流变学与血管新生的影响及其作用机制

目的探讨麝香保心丸对冠心病患者血液流变学与血管新生的影响及其作用机制。方法选取2016年9月—2018年10月收治的冠心病患者102例,按数字表法分为两组,对照组常规治疗,治疗组联合应用麝香保心丸。观察比较两组治疗前后血液流变学相关指标水平的变化情况;相关血清血管新生因子指标:血管内皮生长因子(vascular endothelial growth factor,VEGF)、一氧化氮(NO)及一氧化氮合酶(NOS)的水平变化;发病频率及发病持续时间;两组的临床疗效。结果两组患者治疗后纤维蛋白、血浆黏度及全血黏度均显著低于治疗前(P<0.05),且治疗组纤维蛋白、血浆黏度及全血黏度均显著低于对照组(P<0.05)。两组患者治疗后血清NO、NOS及VEGF的水平均显著高于治疗前(P<0.05),且治疗组血清NO、NOS及VEGF的水平均显著高于对照组(P<0.05)。两组患者治疗后,治疗组发病频率低于对照组(P<0.05),治疗组发病持续时间小于对照组(P<0.05)。两组患者治疗后,治疗组总有效率96.1%高于对照组78.4%,差异有统计学意义(P<0.05)。结论给予冠心病患者进行治疗的过程中联合应用麝香保心丸,可有效降低冠心病患者的相关血液流变学指标,增加相关血清血管新生因子指标水平,进而促使机体建立冠脉侧支循环,降低患者的发病频率、缩短患者的发病持续时间,提高患者的临床疗效。

Effect of Shexiang Baoxin Pills on hemorheology and angiogenesis in patients with coronary heart disease and its mechanism

Objective To explore the effect of Shexiang Baoxin Pills on hemorheology and angiogenesis in patients with coronary heart disease(CHD)and its mechanism.Methods A total of 102 patients with coronary heart disease treated in our hospital from September,2016 to October,2018 were included and divided into two groups by using random number table.The control group was given conventional treatment,while the study group was given Shexiang Baoxin Pills combined with conventional treatment.Hemorheology indexes,related serum angiogenesis factors such as vascular endothelial growth factor(VEGF),nitric oxide(NO)and nitricoxide synthase(NOS),frequency and duration of onset,clinical efficacy in both groups were observed and compared.Results After treatment,fibrin,plasma viscosity and whole blood viscosity in both groups decreased significantly compared with those before treatment(P<0.05),and fibrin,plasma viscosity and whole blood viscosity in the study group were lower than in the control group(P<0.05).In both groups,serum levels of NO,NOS and VEGF increased significantly compared with those before treatment(P<0.05),and the study group had higher levels of NO,NOS and VEGF than the control group(P<0.05).After treatment,the incidence in the study group was lower than in the control group(P<0.05),and the duration of disease in the study group was shorter than in the control group(P<0.05).After treatment,the total effective rate in the study group was 96.1%,which was significantly higher than that(78.4%)in the control group,with statistical significance(P<0.05).Conclusion For CHD patients,Shexiang Baoxin Pills combined with conventional treatment can effectively reduce hemorheology indexes,increase the levels of related serum angiogenesis factors,so as to promote the coronary collateral circulation,reduce the incidence,shorten the duration of onset,and improve the clinical efficacy.