黏膜原发恶性黑色素瘤中C-kit蛋白的表达及临床意义

目的 探讨C-kit蛋白在黏膜原发恶性黑色素瘤(PMMM)的表达及其与浸润和转移的相关性.方法 回顾性分析我院2003年1月-2009年12月收治的18例PMMM患者的临床资料(均经病理组织学检查及免疫组织化学染色确诊),应用免疫组织化学S-P法检测C-kit蛋白的表达,分析和评价PMMM常用临床病理因素对PMMM预后的影响.结果 C-kit蛋白的表达与年龄、性别、病灶直径及预后生存状态等临床病理因素无关(P均＞0.05),而与淋巴结转移密切相关(P＜0.05).结论 C-kit蛋白的表达与淋巴结转移及预后密切相关,其表达丢失可能与PMMM的发生及异常增殖密切相关.

Expression of C-kit protein in primary mucosal mafignant melanoma and its clinical significance

Objective To study the expression of C-kit protein in primary mucosal malignant melanoma(PMMM)and its relation with invasion and metastasis of PMMM.Methods Clinical data about 18 PMMM patients admitted to our hospital from January 2003 to December 2009 with their diagnosis confirmed by histopathology and immunohistochemistry were retrospectively analyzed.Expression of C-kit protein was detected with the immunohistochemistry S-P method.Effect of common clinical and pathological factors for PMMM on its prognosis was analyzed and evaluated.Results The expression of C-kit protein was not related with the clinical and pathological factors for PMMM,including age,gender,prognostic surviving state of the patients and focal diameter of PMMM,but significantly related with lymphatic metastasis of PMMM(P<0.05).Conclusion Expression of C-kit protein is closely related with the lymphatic metastasis and prognosis of PMMM while loss of C-kit protein expression is closely related with the occurrence of PMMM and its abnormal proliferation.