空泡蝶鞍综合征33例临床分析

目的通过对空泡蝶鞍综合征患者的临床资料分析,提高对该疾病的认识。方法对我院2000年1月-2009年3月收治的33例空泡蝶鞍综合征临床资料进行回顾性分析。结果男7例,女26例,年龄（48±16）岁,平均病程4.5年;原发性30例（90.1%）、继发性3例（9.9%）;13例合并高血压病（39.3%）,12例合并脑梗死（36.3%）,5例合并糖尿病（15.2%）;19例为多胎妊娠（57.6%）;肥胖18例（54.5%）,头晕8例（24.2%）,头痛5例（15.2%）,视力损害6例（18.2%）,垂体危象1例（3%）,继发性甲状腺功能减退症5例（15.2%）,继发性性腺功能减退症4例（12.1%）,继发性肾上腺功能减退症3例（9.1%）,高泌乳素血症4例（12.1%）。确诊磁共振为首选,准确率100%。结论空泡蝶鞍伴靶腺功能减退者应尽早激素替代治疗,长期随访垂体功能,预防垂体危象发生。

Empty sella syndrome :A report of 33 cases

Objective To analyze the clinical data about patients with empty sella syndrome（ESS） in an attempt to improve our understanding of ESS. Methods Clinical data about 33 ESS patients admitted to our hospital from January 2000 to March 2009 were retrospectively analyzed. Results Of the 33 patients at the aged 48±16 years, 7 were males and 26 females. The median duration of the disease was 4.5 years. Primary ESS and secondary ESS were found in 30（90.1%） and 3（9.9%） patients, respectively. ESS accompanying hypertension, cerebral infarction, diabetes was found in 13（39.3%）, 12（36.3%）, and 5（15.2%） patients, respectively. Multiple pregnancy, obesity, dizziness, headache, impaired vision, pituitary crisis, secondary hypothyroidism, secondary hypogonadism, and hyperprolactinemia were diagnosed in 19（57.6%）, 18（54.5%）, 8（24.2%）, 5（15.2%）, 6（18.2%）, 1（3%）, 5（15.2%）, 4（12.1%）, and 3（9.1%） patients, respectively. The diagnosis depended on CT. MRI was the first choice with an accurate of 100%. Conclusion Patients with ESS accompanying hypoadenia should be treated with hormones as early as possible and followed up for a long time in order to prevent pituitary crisis.