| 竹叶提取物的抗血栓作用研究 |
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| 引用本文： | 李少鹏,王成林,潘蔚然,蔡侃之.竹叶提取物的抗血栓作用研究[J].中国热带医学,2005,5(6):1202-1204. |
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| 作者姓名： | 李少鹏 王成林 潘蔚然 蔡侃之 |
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| 作者单位： | 1. 东莞市人民医院神经外科,广东,东莞,523018
2. 中国医科大学第二临床学院神经外科,辽宁,沈阳,110016 |
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| 摘 要： | 目的研究竹叶提取物的抗血栓作用。方法采用小白鼠体外凝血时间及家兔血浆凝血酶原时间(PT)、家兔血浆白陶土部分凝血活酶时间(KPTT)、家兔血浆凝血酶时间(ThrombinTime)和ADP诱导的家兔血小板聚集实验来观察竹叶提取物的抗血栓作用。结果竹叶提取物22.5mg/kg、45mg/kg和90mg/kg能显著延长小鼠体外凝血时间;7.5mg·mL～1、15.0mg·mL-1和30.0mg/kg能明显延长血浆凝血酶原时间、白陶土活化部分凝血活酶时间及凝血酶时间,并能显著抑制ADP引起的血小板聚集。结论竹叶提取物具有明显的抗血栓形成作用。
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| 关 键 词： | 竹叶提取物（BLE） 香丹注射液（XDU） 抗血栓 血小板聚集 凝血时间 |
| 文章编号： | 1009-9727(2005)06-1202-03 |
| 收稿时间： | 03 10 2005 12:00AM |
| 修稿时间： | 2005年3月10日 |
Study on the antithrombotic effect of bamboo leave extract |
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| LI Shao-peng,WANG Cheng-lin,PAN Wei-ran,et al..Study on the antithrombotic effect of bamboo leave extract[J].China Tropical Medicine,2005,5(6):1202-1204. |
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| Authors: | LI Shao-peng WANG Cheng-lin PAN Wei-ran |
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| Abstract: | Objective To study the antithrombotic effect of BLE. Methods Thrombin time (TT), prothrombin time (PT), KPTT in rabbits and clotting time in mice, Platelet aggregation induced by ADP in the rabbits were studied in this paper. Results Thrombin time (TT) ,prothrombin time (PT), KPTT in rabbits and clotting time in mice were prolonged significantly. Platelet aggregation induced by ADP in the rabbits was inhibited. Conclusion BLE significantly inhibited the formation of arteris thrombus in the rabbits. |
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| Keywords: | BLE XDIJ antithrombotic platelet aggregation clotting time |
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