| 蜂胶胶囊的毒理学安全性评价 |
| |
| 引用本文： | 冯丁山,郑定仙,黄业宇,王湛,张晓昕.蜂胶胶囊的毒理学安全性评价[J].中国热带医学,2010,10(4):454-455. |
| |
| 作者姓名： | 冯丁山 郑定仙 黄业宇 王湛 张晓昕 |
| |
| 作者单位： | 海南省疾病预防控制中心,海南海口,570203 |
| |
| 摘 要： | 目的对蜂胶胶囊的食用安全性进行毒理学实验评价。方法采用小鼠急性经口毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)和30d喂养试验进行检测评价。结果小鼠急性经口毒性MTD20.0g/kg.bw,三项遗传毒性试验结果均为阴性。30d喂养试验未显示明显毒性。结论蜂胶胶囊急性毒性分级属无毒级、无遗传毒性,初步估计最大无损害作用剂量大于人体推荐摄入量的100倍。
|
| 关 键 词： | 蜂胶 急性毒性 遗传毒性 30d喂养试验 安全性 |
Evaluation of toxicity of Propolis capsule. |
| |
| FENG Ding-shan,ZHENG Ding-xian,HUANG Ye-yu,et al..Evaluation of toxicity of Propolis capsule.[J].China Tropical Medicine,2010,10(4):454-455. |
| |
| Authors: | FENG Ding-shan ZHENG Ding-xian HUANG Ye-yu |
| |
| Affiliation: | FENG Ding-shan,ZHENG Ding-xian,HUANG Ye-yu,et al.(Hainan Provincial Centre for Disease Control , Prevention,Haikou 570203,Hainan,P,R.China) |
| |
| Abstract: | Objective To assess the edible safety of Propolis capsule. Methods The toxicity was determined by acute toxicity test and thirty-day feeding tests. The mutations of Propolis capsule was tested using micronucleus test in bone marrow cell,sperm shape abnormality test and Ames test. The teratogenicity was also assessed. Results The acute oral MTD in mice was over 20.0g/kg.bw. The results of micronucles test in bone marrow cell,sperm shape abnormality,Ames test were negative,without significant differences. Con... |
| |
| Keywords: | Propolis Acute toxicity Mutagenicity test Thirty-day feeding tests Safety evaluation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
