延胡索、乌药、金铃子散、小活络丹对神经病理性疼痛镇痛作用的比较

目的：比较延胡索、乌药、金铃子散、小活络丹对坐骨神经缩窄性损伤（chronic constriction injury，CCI）模型大鼠神经病理性疼痛（neuropathic pain，NP）的镇痛效果。方法：将SD 雄性大鼠随机分为假手术组（n=13）、生理盐水组（n=13）、延胡索组（n=16）、乌药组（n=10）、金铃子散组（n=20）、小活络丹组（n=7），共6 组。采用坐骨神经结扎法造模，于造模后第4 天各组给予相应的药物（延胡索组、乌药组、金铃子散组、小活络丹组大鼠均按剂量12 g·kg-1 给药，假手术组、生理盐水组给予等量生理盐水）灌胃，连续14 天。从开始给药起，每隔1 天测定其热痛阈值。结果：与生理盐水组比较，延胡索、乌药、金铃子散、小活络丹各组大鼠给药后热痛阈值均升高，金铃子散的效果稍微优于延胡索，乌药、小活络丹效果较差。结论：延胡索、乌药、金铃子散、小活络丹对神经病理性疼痛均具有一定的镇痛作用，其中金铃子散的镇痛作用较强且起效快，其次为延胡索，乌药和小活络丹对该种神经病理性疼痛的镇痛效果较不稳定。

Comparison of Analgesic Effects of Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan on Rats with Neuropathic Pain#br#

Objective：To compare the analgesic effects of Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan on chronic neuropathic pain in rats with sciatic nerve chronic constriction injury （CCI）. Methods：The male SD rats were randomly divided into 6 groups，sham operation group （n=13），saline group （n=13），Corydalis Yanhusuo group （n=16）， Radix Lindera group （n=10），Jin Ling-zi powder group （n=20） and Xiao Huo-luo Dan group （n=7），respectively. Four days after the CCI surgery，the drugs were given by intragastric administration. The rats in Corydalis Yanhusuo group，Radix Lindera group，Jin Ling-zi powder group and Xiao Huo-luo Dan group were given 12 g·kg-1 drug respectively. The sham operation group and saline group were given the same amount of saline. The rats were administered intragastrically once a day for 14 consecutive days. From the beginning of the administration，the threshold of thermal pain was measured every other day by hot needling instrument. Results：Compared with Controlgroup，the thermal threshold of Corydalis Yanhusuo group，Radix Lindera group，Jin Ling-zi powder group and Xiao Huo-luo Dan group were all increased，but the increase of Corydalis Yanhusuo group and Jin Ling-zi powder group were more significantly. Conclusion：Corydalis Yanhusuo，Radix Lindera，Jin Ling-zi powder and Xiao Huo-luo Dan all have analgesic effect on neuropathic pain，among which Jin Ling-zi powder has the strongest analgesic effect and the fastest curative effect，followed by Corydalis Yanhusuo. The analgesic effects of Radix Lindera and Xiao Huo-luo Dan were not stable.