5-HT2A/D2 受体平衡拮抗剂NH809抗精神分裂症作用的初步研究 |
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作者姓名: | 于民权 徐祥清 |
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作者单位: | 江苏恩华药业股份有限公司,徐州,221000,中国 |
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摘 要: | 目的:考察5-HT2A/D2 受体平衡拮抗剂NH809 体内抗精神分裂症药理学作用。方法:采用地卓西平马来酸盐(0.3 mg·kg-1,ip)诱发小鼠高活动模型、阿扑吗啡(1 mg·kg-1,sc)诱导小鼠攀爬模型及大鼠条件回避反应(conditioned avoidance response,CAR)实验,评估NH809 体内抗精神分裂症的作用,并与阳性药利培酮进行比较。结果:在地卓西平马来酸盐诱发小鼠高活动模型、阿扑吗啡诱导小鼠攀爬行为及大鼠条件回避反应体内动物
模型上,NH809 具有剂量相关的抑制作用,其ED50 分别为0.04、0.05 和0.24 mg·kg-1;利培酮在这三个模型上的ED50 分别为0.06、0.68 和0.60 mg·kg-1。结论:NH809 对多个精神分裂症动物模型具有显著的药理学作用,且体内活性优于利培酮。
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关 键 词: | 5-HT2A/D2 受体平衡拮抗剂 高活动 攀爬 条件回避 |
A Preliminary Study on the Effect of 5-HT2A/D2 Receptor Balancing Antagonist NH809 on Schizophrenia |
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Authors: | YU Min-quan XU Xiang-qing |
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Affiliation: | Jiangsu Nhwa Pharmaceutical Co.,Ltd,Xuzhou,221000,China |
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Abstract: | Objective:To investigate the pharmacological effects of 5-HT2A/D2 receptor balancing antagonist NH809 on schizophrenia in vivo. Methods:The effects of NH809 on schizophrenia in vivo were evaluated by MK-801 hydrogen maleat(0.3 mg·kg-1,ip) induced hyperactivity model in mice,apomorphine (1 mg·kg-1,sc) induced climbing model in mice and conditioned avoidance response(CAR) in rats,and compared with risperidone. Results:NH809 had dose-dependent inhibitory effect on MK-801 hydrogen maleate induced high activity model,apomorphine-induced climbing behavior in mice and conditioned avoidance response in vivo,with ED50 of 0.04,0.05 and 0.24 mg·kg-1,respectively. The ED50 of risperidone in these three models were 0.06,0.68 and 0.60 mg·kg-1,respectively. Conclusion:NH809 has significant pharmacological effects on several animal models of schizophrenia,and its activity in vivo is better than risperidone. |
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Keywords: | 5-HT2A/D2 receptor balance antagonist hyperactivity climbing behavior CAR |
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