右美托咪啶对男性患者全麻苏醒期导尿管相关膀胱刺激征的作用

目的：观察右美托咪啶对男性患者全麻苏醒期导尿管相关膀胱刺激征（CRBD）的作用。方法：择期全麻下手术男性患者150例,随机分为对照组（C组）和右美组（D组）,每组75例。C组给予咪唑安定0.03 mg·kg-1、芬太尼3μg·kg-1、丙泊酚1.5 mg·kg-1、琥珀胆碱2 mg·kg-1诱导,气管插管后静脉注射顺阿曲库铵0.1 mg·kg-1、芬太尼4μg·kg-1,泵入丙泊酚60-70μg·kg-1·min-1、顺阿曲库铵2-3μg·kg-1·min-1和瑞芬太尼0.1-0.3μg·kg-1·min-1维持麻醉。D组在气管插管后静脉泵入右美托咪啶1μg·kg-1,1 h泵完,余均同C组。两组均在诱导后放置导尿管,观察两组苏醒时间、苏醒期平均动脉压（MAP）和心率（HR）变化,并评估入麻醉恢复室（PACU）后CRBD发生率和严重程度。结果：与麻醉前比,苏醒期MAP和HR在D组无明显变化,而C组明显升高,两组比较差异有统计学意义（P〈0.05）;D组CRBD发生率和严重程度明显低于C组（P〈0.01或P〈0.05）。结论：右美托咪啶1μg·kg-1静脉泵入可降低男性患者全麻苏醒期CRBD发生率及严重程度,提高患者导尿后舒适度。

Effects of dexmedetomidine on catheter-related bladder discomfort post general anesthesia recovery period in male adult patients

Objective： To investigate the effects of dexmedetomidine on catheter-related bladder discomfort（ CRBD） post general anesthesia recovery period in male adult patients. Methods： One hundred fifty male adult patients with general anesthesia who undergoing selective surgery were randomized into two groups with 75 cases in each group. The patients in group C（ control group） were received anesthetic induction by midazolam 0. 03 mg·kg-1,fentanyl 3 μg·kg-1,propofol 1. 5 mg·kg-1and scoline 2 mg · kg-1. After intubation,cisatracurium0. 1 mg·kg-1and fentanyl 4 μg·kg-1were injected,then propofol 60-70 μg·kg-1·min-1,cisatracurium2-3 μg·kg-1·min-1and remifentanil 0. 1-0. 3 μg·kg-1·min-1were infused. The patients in group D（ dexmedetomidine group） were infused by dexmedetomidine 1 μg·kg-1（ continued one hour） after intubation,the others were same in group C. After anesthesia induction,all patients were catheterized with urethral catheters. The recover time of anesthesia,MAP and HR were recorded. The incidence and severity（ mild,moderate,and severe）of CRBD were assessed during recovery period in PACU. Results： Compared with before anesthesia,MAP and HR during recovery period were no significantly change in group D,but were significantly higher in group C（ P 〈0. 05）. The incidence and severity（ mild,moderate,and severe） of CRBD in group D were significantly lower than that in group C（ P 〈 0. 01 or P 〈 0. 05）. Conclusion： Dexmedetomidine 1 μg·kg-1can significantly reduce CRBD post general anesthesia recovery period in male adult patients. MoreBack