趋化因子CXCL12及受体CXCR4在胃癌中的研究进展

趋化因子CXCL12及其受体CXCR4在胃癌生长、侵袭、转移和胃癌新生血管的形成等方面发挥着重要作用。统计学分析表明CX-CR4阳性表达率与胃癌腹膜转移有关(P<0.001);CXCL12/CXCR4可以调节多种肿瘤细胞的增殖,包括乳腺癌、前列腺癌、黑色素瘤以及消化道癌等;它们的过度表达可以增加肿瘤血管和淋巴管生成,促进肿瘤的生长与侵袭转移;还可以趋化血管内皮细胞的聚集,诱导微血管的形成和毛细血管的发生。这些发现都提示着CXCL12及受体CXCR4与胃癌发生、发展和迁徙转移过程中有密切关系。因此,对CXCL12/CXCR4的深入研究将有望使其成为胃癌靶向治疗的新靶点。

Research Progress of Chemotactic Cytokines CXCL12 and Receptor CXCR4 in Gastric Cancer

It plays important role of chemotactic cytokines CXCL12 and receptor CXCR4 during growth,invasion and metastasis of gastric cancer and forming of neovascularization.The statistic analysis shows that the positive rate of CXCR4 is related to peritoneal metastasis of gastric cancer(P<0.01).CXCL12/CXCR4 can regulate proliferation of tumor cells including breast cancer,prostate cancer,melanoma,and digestive tract cancer and so on;their over-expression increase the growth of tumor vessels and lymphatic that promote the growth of tumor and invasion and metastasis;it also can promote chemotactic gathering of vascular endothelial cells inducing the form of microvessel and the occurrence of capillary.It indicates that there is close relationship among CXC12 and receptor CXCR4 and the occurrence,development and metastasis of gastric cancer.Therefore,the deep research on CXCL12/CXCR4 hopefully can make targeted therapy of gastric cancer become a new target.