| 羰基镍急性吸入性致毒的研究 |
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| 引用本文： | 尚慧,马国煜,王秋英,张昆,宣小强,兰晓君,徐东伟,任秀芳.羰基镍急性吸入性致毒的研究[J].甘肃医药,2011(9):513-517. |
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| 作者姓名： | 尚慧 马国煜 王秋英 张昆 宣小强 兰晓君 徐东伟 任秀芳 |
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| 作者单位： | 金川集团有限公司职工医院职业病科; |
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| 摘 要： | 目的：掌握不同剂量羰基镍气体吸入后不同时间段大鼠血清、脏器镍含量、血清酶及病理变化的规律,为临床诊断急性羰基镍中毒提供理论依据。方法：以20mg/m3、135mg/m3、250mg/m3羰基镍气体让受试大鼠吸入30min,24h、48h、72h、7d分别将大鼠麻醉处死,采集血液、脏器标本,测定血清镍、脏器镍、血清酶及观察脏器病理变化,并设正常对照组进行统计学分析。结果：染毒组血清镍含量升高,与对照组比较差异有显著性,且随吸入浓度增加血清镍含量逐渐升高;天冬氨酸氨基转移酶、肌酸激酶、乳酸脱氢酶不同程度增高;肺脏病理变化显著,主要为急性气道损伤及急性肺泡损伤。结论：羰基镍急性染毒后肺脏为首要靶器官,造成的损害与吸入剂量呈明显的剂量-效应关系。
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| 关 键 词： | 羰基镍 急性 染毒 损害 |
Study on acute inhalation toxicity by nickel carbonyl in rats |
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| Authors: | SHANG Hui MA Guo-yu WANG Qiu-ying ZHANG Kun XUAN Xiao-qiang LAN Xiao-jun XU Dong-wei REN Xiu-fang |
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| Affiliation: | SHANG Hui MA Guo-yu WANG Qiu-ying ZHANG Kun XUAN Xiao-qiang LAN Xiao-jun XU Dong-wei REN Xiu-fang Department of Occupational disease,the Worker's Hospital of Jinchuan Company,Jinchang 737103,China |
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| Abstract: | Objective:To investigate the SD rat content of serum nickel,organ nickel after inhaling different dose nickel carbonyl in different time periods and serum ferment,pathological changes in different time periods,and to provide theoretical basis for diagnosing patients with acute toxicity of nickel carbonyl.Methods:Healthy SD rats were acutely exposed inhaling different concentrations of carbonyl nickel(20mg/m3,135mg/m3,250mg/m3)for 30 minutes,24 hours,48 hours,72 hours and 7 days in which the content of serum... |
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| Keywords: | nickel carbonyl acute exposure injury |
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