前列腺素E_1与弥可保联合治疗糖尿病周围神经病变疗效观察

目的:观察前列腺素E1(PGE1)与弥可保联合治疗糖尿病周围神经病变的临床疗效。方法:选用一般情况具有可比性的糖尿病周围神经病变患者,将其随机分成两组,治疗组22例,对照组18例,治疗组用PGE1100U加生理盐水500mL静滴,1次/d,同时应用弥可保500μg,肌肉注射,1次/d,连续2周。对照组应用弥可保500μg,肌肉注射,1次/d,连续2周。结果:治疗14d后两组评分较前明显下降,但以治疗组下降显著,治疗后两组平均评分有显著差异性(P<0.01)。结论:表明前列腺素E1(PGE1)与弥可保联合治疗糖尿病周围神经病变安全有效,使糖尿病周围神经病变患者临床症状显著改善。

Therapeutic Observation of Prostaglandin E1 and Methycobal on Diabetic Peripheral Neuropathy

Objective:To state the clinical efficacy of prostaglandin E_1(PGE_1) and methycobal on diabetic peripheral neuropathy.Methods: Two groups of patients who had diabetic peripheral neuropathy with comparative conditions were randomly divided into a therapeutic group(22 cases)and a control group(18cases).The patients of the therapeutic group were given PGE_1 100U dissolved in 0.9%natrii chloridi 500mL once a day intravenously,and given methycobal 500μg once a day intramuscular,and in the control group were given methycobal 500μg once a day intramuscular.Two groups of patients all had 14days one course of treatment.Rusults:The comparison of two groups descent more distinct than before 14 days treatment,but the therapeutic group was more great,the average comparison of two groups had great distinct difference(P<0.01) after treatment.Conclusion: The therapeutic effects in the treatment of PGE_1 and methycobal on diabetic peripheral neuropathy is obvious.The clinical symptoms are singnificantly improved in the patients of the therapeutic group.