低分子肝素钠联合丹奥治疗脑梗死疗效观察

目的:观察低分子肝素钠联合丹奥(注射用奥扎格雷钠)治疗急性脑梗死(ACI)的疗效和不良反应。方法:104例ACI患者随机分为治疗组和对照组各52例,两组均常规应用低分子右旋糖酐500mL加维脑路通400mg静滴,1次/d。治疗组在此基础上加用低分子肝素钠5000U皮下注射,1次/d,丹奥80mg静滴,1次/d,疗程均为2周。观察两组患者治疗前后神经功能缺损评分,血小板聚集率的变化。结果:治疗组的总有效率及治疗后血小板聚集率与对照组比较,差异有显著性(P<0.05),治疗组神经功能缺损评分与对照组比较差异有极显著性(P<0.01)。结论:低分子肝素钠联合丹奥对急性脑梗死有较好的疗效,无明显不良反应。

Clinical Observation of Low Molecular-Weight Heparin Sodium Combined with Dan'ao in Treating Cerebral Infarction

Objective: To observe clinical effect and side-effect of low molecular-weight heparin(LMWH) sodium combined with dan'ao(Ozagrel) in treating acute cerebral infarction(ACI).Methods: 104 cases of ACI were allocated randomly into two groups:treatment group and control group(52 cases in every group).The treatment group was given 5000U LMWH subcutaneously,once a day;80mg of dan'ao intravenously,once a day.The changes of the neurological deficit scores and platelet aggregation rate after treatment were observed in both groups.Results:The defference of total effective rate and platelet aggregation rate in the treatment group was significant compared to the control group(P<0.05),the neurological deficit scores of treatment group decreased very significantly,compared to the control group(P<0.01).Conclusion:LMWH combined with dan'ao is effective in treatment of ACI,without obvious side-effect.