钴合金裸支架与雷帕霉素药物涂层支架在冠心病患者应用中的对比研究

目的比较冠状动脉内钴合金裸支架与雷帕霉素药物支架特点、临床应用的安全性和有效性,探讨钴合金裸支架治疗单支冠状动脉病变冠心病患者的安全性和临床疗效。方法分析经选择性冠状动脉造影(CAG)证实为单支病变血管直径狭窄>70%的冠心病患者204例,81例冠状动脉内置入钴合金裸支架;123例冠状动脉内置入雷帕霉素药物涂层支架,观察术后疗效、12个月内主要不良心脏事件(MACE)发生率及再狭窄率。结果两组手术成功率均为100%。两组患者置入支架的成功率、住院期间急性及亚急性血栓形成率及12个月随访MACE发生率、再狭窄率等差异无统计学意义。结论钴合金裸支架可以安全有效的应用于单支冠状动脉病变的治疗。

Comparison between Sirolimus-eluting Stents and Cobalt Alloy Bare Stents in Coronary Artery Disease

Objective To compared with the characteristics,clinical safety and validity of Sirolimus-eluting stents and Cobalt alloy bare stents. Methods 204 patients with coronary artery stenosis over 70 % in area confirmed by coronary angiography were enrolled in this study. Cobalt alloy bare stents were implanted in 81 patients,and Sirolimus-eluting stent were implanted in 123 patients. The therapeutic effect,major adverse cardiac events(MACE) and restenosis were investigated. Results Rates of successful operation were 100 % in both groups. There was no significant difference between two groups of patients in stent implantation success rate during hospitalization and in MACE rate during 12-month follow-up. The aspect of depressing the restenosis rate of Sirolimus-eluting stent surpassed that of Cobalt alloy bare stents. Conclusion Sirolimus-eluting stents and Cobalt alloy bare stents are safe and effective in coronary artery disease.